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TranscriptomicsIdentification of common features proffered by KIT and PDGFRA mutations in gastro-intestinal stromal tumors
Mutations in KIT proto-oncogene receptor tyrosine kinase (KIT) or platelet derived growth factor receptor alpha (PDGFRA) are responsible for more than 85% of the gastrointestinal stromal tumors (GIST). The introduction of imatinib in the therapy scheme of GIST revolutionized the patient outcome. Unf...
ORGANISM(S): Homo sapiens 
2017-07-05 | E-MTAB-4548 | biostudies-arrayexpress
TranscriptomicsDeletion of chromosome 4q predicts outcome in Stage II colon cancer
Background: Around 30% of all stage II colon cancer patients will relapse and die of their disease. At present no objective parameters for identification of high-risk stage II colon cancer patients, who will benefit from adjuvant chemotherapy, are established. With traditional histopathological feat...
ORGANISM(S): Homo sapiens 
2010-07-13 | E-GEOD-17181 | biostudies-arrayexpress
TranscriptomicsThree commercial array platforms compared for DNA copy number detection with DNA isolated from FFPE tissue [NimbleGen]
Formalin-fixed, paraffin-embedded (FFPE) archival tissue is an important source of DNA material. The most commonly used technique to identify copy number aberrations from chromosomal DNA in tumorigenesis is array comparative genomic hybridization (aCGH). Although copy number analysis using DNA from ...
ORGANISM(S): Homo sapiens 
2012-01-17 | E-GEOD-30120 | biostudies-arrayexpress
TranscriptomicsThree commercial array platforms compared for DNA copy number detection with DNA isolated from FFPE tissue [Agilent]
Formalin-fixed, paraffin-embedded (FFPE) archival tissue is an important source of DNA material. The most commonly used technique to identify copy number aberrations from chromosomal DNA in tumorigenesis is array comparative genomic hybridization (aCGH). Although copy number analysis using DNA from ...
ORGANISM(S): Homo sapiens 
2012-01-17 | E-GEOD-30121 | biostudies-arrayexpress
UnknownReconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.
Not available
S-EPMC7002414 | biostudies-literature
UnknownCombined burden and functional impact tests for cancer driver discovery using DriverPower.
Not available
S-EPMC7002750 | biostudies-literature
UnknownCancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis.
Not available
S-EPMC7002399 | biostudies-literature
UnknownHigh-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Not available
S-EPMC7002524 | biostudies-literature
UnknownPathway and network analysis of more than 2500 whole cancer genomes.
Not available
S-EPMC7002574 | biostudies-literature
UnknownIntegrative pathway enrichment analysis of multivariate omics data.
Not available
S-EPMC7002665 | biostudies-literature
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