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TranscriptomicsThe effect of HES6 silencing on the gene expression profiles of the glioblastoma A172 and LN405 cell lines
Malignant glioma is the most common type of primary brain tumor diagnosed annually in 16,000 individuals in the United States. We performed a systematic large-scale transcriptomics data mining study of 9,783 Affymetrix samples from the GeneSapiens database in order to identify those genes that are m...
ORGANISM(S): Homo sapiens 
2011-06-30 | E-GEOD-22692 | biostudies-arrayexpress
TranscriptomicsThe effect of miRNA overexpression on gene expression profile of MCF-7 cells
To identify microRNAs impacting estrogen receptor ERα expression in breast cancer, we have screened ER-positive breast cancer cells with a library of pre-miRs, and systematically monitored the ERα expression by protein lysate microarrays. There was a significant enrichment of the in silico predict...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14847 | biostudies-arrayexpress
TranscriptomicsInhibition of dihydroorotate dehydrogenase by doxorubicin and brequinar sensitize cancer cells to TRAIL-induced apoptosis
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent in selectively killing tumor cells. However, TRAIL monotherapy is not especially successful due to the fact that many cancer cells are resistant to TRAIL. Chemotherapeutic agents, such as doxorubicin have been shown...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-42531 | biostudies-arrayexpress
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