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TranscriptomicsUbiquinol-induced gene expression signatures are translated into reduced erythropoiesis and LDL cholesterol levels in humans
Studies in vitro and in mice indicate a role for Coenzyme Q10 (CoQ10) in gene expression. To determine this function in relationship to physiological readouts, a 2-week supplementation study with the reduced form of CoQ10 (ubiquinol, Q10H2, 150 mg/d) was performed in 53 healthy males. Mean CoQ10 pla...
ORGANISM(S): Homo sapiens 
2013-04-08 | E-GEOD-21351 | biostudies-arrayexpress
TranscriptomicsDefining the microglia transcriptome in multifunctional protein-2 deficient mice
Purpose: We purified whole brain microglia of MFP2 knockout mice and control mice utilizing percoll gradient and FACS sorting, followed by microarray analysis to define the molecular changes in MFP2 knockout mice at the endstage of the disease. We compared the microglia transcriptome of Mfp2-/- micr...
ORGANISM(S): Mus musculus 
2015-04-14 | E-GEOD-66420 | biostudies-arrayexpress
TranscriptomicsHigh VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia.
High VEGFC mRNA expression of AML blasts is related to increased in vitro and in vivo drug resistance. The prognostic significance of VEGFC on long-term outcome and its associated gene expression profiles remain to be defined. We studied the effect of VEGFC on treatment outcome and investigated gene...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22056 | biostudies-arrayexpress
TranscriptomicsThe leukemia-specific fusion gene ETV6/RUNX1 perturbs distinct key biological functions primarily by gene repression
Background: ETV6/RUNX1 (E/R) (also known as TEL/AML1) is the most frequent gene fusion in childhood acute lymphoblastic leukemia (ALL) and also most likely the crucial factor for disease initiation, whereas its role in leukemia propagation and maintenance remains largely elusive. To address this iss...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-29639 | biostudies-arrayexpress
TranscriptomicsExpression data from Pseudomonas aeruginosa PAO1 and an isogenic HCN negative mutant (PAO6344), grown under cyanogenic conditions.
Pseudomonas aeruginosa produces the toxic secondary metabolite hydrogen cyanide (HCN) at high cell population densities and low aeration. We have used Affimetrix microarrays to investigate the impact of HCN as a signal in cell-cell communication by comparing the transcriptome of the wild-type strain...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2013-09-16 | E-GEOD-48587 | biostudies-arrayexpress
ProteomicsA SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Purposing
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 170,000 people since the end of 2019, killed over 7,400, and caused worldwide social and economic disruption. SARS-CoV-2 infection has a mortality rate of 3.4% among confirmed case...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 (ncbitaxon:2697049) Homo Sapiens (ncbitaxon:9606) 
2020-03-24 | MSV000085144 | MassIVE
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