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Background and Aims: Chronic HBV infection is a major cause of liver disease and cancer. Virus-host interactions and the pathogenesis of virus-induced liver disease are only partially understood. Hypoxia has been shown to play a major role in disease biology and carcinogenesis and HBV replicates a n...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2023-07-20 | PXD020086 | Pride
Human cytomegalovirus (HCMV) is an important pathogen that extensively modulates host cells, downregulating >900 human proteins over the course of viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins remains unresolved, and the fun...
ORGANISM(S): Human herpesvirus 5 strain Merlin Homo sapiens (Human) Betaherpesvirinae 
2020-01-22 | PXD014845 | Pride
Vaccinia virus (VACV) has numerous immune evasion strategies, including multiple mechanisms of inhibition of IRF-3, NF-κB and type I interferon (IFN) signaling. Here, we used highly multiplexed proteomics to quantify >8,000 cellular proteins and ~80% of viral proteins over seven time points spanning...
ORGANISM(S): Vaccinia virus Western Reserve Homo sapiens (Human) Vaccinia virus 
2019-05-07 | PXD012785 | Pride
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