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TranscriptomicsThe structure of human Argonaute-2 in complex with miR-20a
Argonaute proteins lie at the heart of the RNA-Induced Silencing Complex (RISC), wherein they use small RNA guides to recognize targets. Some Argonaute proteins can directly cleave their targets, whereas others recruit co-factors to repress independently of “slicing.” Prior studies established the a...
ORGANISM(S): Spodoptera frugiperda 
2012-05-12 | E-GEOD-37931 | biostudies-arrayexpress
TranscriptomicsProbing the initiation and effector phases of the somatic piRNA pathway in Drosophila
Combining RNAi in cultured cells and analysis of mutant animals, we probed roles of known piRNA pathway components in the initiation and effector phases of transposon silencing. total RNA and RNA associated with Piwi was isolated and size-fractionated by PAGE into 19-29nt. These were processed and s...
ORGANISM(S): Drosophila melanogaster 
2010-10-25 | E-GEOD-24108 | biostudies-arrayexpress
TranscriptomicsThe Making of a Slicer: Activation of Human Argonaute-1
The Argonautes are the central protein component in small RNA silencing pathways. Of the four human Argonautes (hAgo1-4) only hAgo2 is an active slicer. We determined the structure of hAgo1 bound to endogenous copurified RNAs to 1.75 Å resolution and hAgo1 loaded with let-7 miRNA to 2.1 Å. Both stru...
ORGANISM(S): Spodoptera frugiperda 
2013-05-20 | E-GEOD-46870 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the genetic regulation of gene expression in human neutrophils
Here we report an expression dataset of isolated neutrophils from 114 healthy individuals of Chinese ethnicity collected in Singapore. A total of 114 individuals with no case control stratification.
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-70044 | biostudies-arrayexpress
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