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ProteomicsProteomes of chromatin fractions derived from SU-DHL-5 cells
SU-DHL-5 cells display limited expression of the SUMO isopeptidase SENP6. In this experiment, the chromatin associated fraction of SU-DHL-5 cells was analysed by mass spectrometry. SU-DHL-5 cells were either stably transfected with an empty vector or with a SENP6 expression construct. Changes in pro...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027355 | Pride
Su-dhl-5 cells (b-cell lymphoma) 
ProteomicsActivated SUMOylation restricts the MHC class I antigen presentation pathway to confer immune evasion in cancer
Activated SUMOylation is a hallmark of aggressive cancers. Starting from a targeted screening for SUMO-regulated immune evasion mechanisms, we identified an evolutionary conserved function of activated SUMOylation, which attenuates the immunogenicity of tumor cells. Activated SUMOylation allows canc...
ORGANISM(S): Homo sapiens (Human) 
2022-01-15 | PXD030506 | Pride
Human B-cell lymphoma 
TranscriptomicsGene expression profiling in isogenic p53wt/p53ko Burkitt lymphoma cell line Seraphine after shRNA-mediated knock-down of p53 pathway members
We performed an shRNA-based RNAi interference screen targeting around 5,000 genes in eight Burkitt lymphoma cell lines. MDM4 and CDKN3 were essential genes in four p53 wild-type Burkitt lymphoma cell lines, but not in four p53 mutant cell lines. To investigate the effect of the gene knock-down on ce...
ORGANISM(S): Homo sapiens 
2019-08-01 | E-MTAB-7134 | biostudies-arrayexpress
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