Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of human airway epithelium, large airways, phenotypically normal smokers vs non-smokers, MAS5 (HuGeneFL)
Upregulation of Expression of the Ubiquitin Carboxyl Terminal Hydrolase L1 Gene in Human Airway Epithelium of Cigarette Smokers; The microarray data deposited here is from 44 HuGeneFL GeneChips, from 9 normal non-smokers and 13 phenotypic normal smokers, large airways, 2 samples per individual, one ...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-5056 | biostudies-arrayexpress
TranscriptomicsQuality Control in Microarray Assessment of Gene Expression in Human Airway Epithelium
Microarray technology provides a powerful tool for defining gene expression profiles of airway epithelium that lend insight into the pathogenesis of human airway disorders. The focus of this study was to establish rigorous quality control parameters to ensure that microarray assessment of the airway...
ORGANISM(S): Homo sapiens 
2010-09-19 | E-GEOD-11906 | biostudies-arrayexpress
TranscriptomicsThe Human Airway Epithelial Basal Cell Transcriptome
Background. The human airway epithelium consists of 4 major cell types: ciliated, secretory, columnar and basal cells. During natural turnover and in response to injury, the airway basal cells function as stem / progenitor cells for the other airway cell types. The objective of this study is to bett...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-24337 | biostudies-arrayexpress
TranscriptomicsSmoking-induced Wnt pathway downregulation
The Wnt pathway plays a central role in controlling differentiation of epithelial tissues; when Wnt is on, differentiation is suppressed, but when Wnt is off, differentiation is allowed to proceed. Based on this concept, we hypothesized that expression of key genes in the Wnt pathway are suppressed ...
ORGANISM(S): Homo sapiens 
2011-04-20 | E-GEOD-19407 | biostudies-arrayexpress
TranscriptomicsModulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking COPD and Lung Cancer
Cystatin A (gene: CSTA), is up-regulated in non-small-cell lung cancer (NSCLC) and dysplastic vs normal human bronchial epithelium. In the context that chronic obstructive pulmonary disease (COPD), a small airway epithelium (SAE) disorder, is independently associated with NSCLC (especially squamous ...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-22047 | biostudies-arrayexpress
TranscriptomicsRNA-Seq Quantification of the Transcriptome of Genes Expressed in the Small Airway Epithelium of Nonsmokers and Smokers
The small airway epithelium (SAE) the pseudostratified epithelium that covers the majority of the human airway surface from the 6th generation to the alveoli, is the major site of lung disease caused by smoking, and the cell population that exhibits the earliest manifestations of smoking-induced dis...
ORGANISM(S): Homo sapiens 
2012-03-05 | E-GEOD-27681 | biostudies-arrayexpress
TranscriptomicsAirway Basal Cells of Healthy Smokers Express an Embryonic Stem Cell Signature Relevant to Lung Cancer
Activation of the human embryonic stem cell (hESC)-signature genes has been observed in various epithelial cancers. In this study, we found that the hESC signature is selectively induced in the airway basal stem/progenitor cell population of healthy smokers (BC-S), with a pat-tern similar to that ac...
ORGANISM(S): Homo sapiens 
2014-09-09 | E-GEOD-19722 | biostudies-arrayexpress
TranscriptomicsSmoking Dysregulates the Human Airway Basal Cell Transcriptome at COPD-linked Risk Locus 19q13.2
Rationale: Genome-wide association studies (GWAS) and candidate gene studies have identified a number of loci linked to susceptibility of chronic obstructive pulmonary disease (COPD), a smoking-related disorder that originates in the airway epithelium. Objectives: Since airway basal cell (BC) stem/p...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-47718 | biostudies-arrayexpress
Sort   by:  
 Page size