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GenomicsGenome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4
IRF5 and STAT4 are strongly associated with human systemic lupus erythematosus (SLE). By performing chromatin immunoprecipitation-sequencing (ChIP-Seq) in human peripheral blood mononuclear cells (PBMCs), we identified more than 7000 target genes for IRF5 and STAT4 in stimulated PBMCs. Contrarily, w...
ORGANISM(S): Homo sapiens 
2012-06-08 | E-GEOD-38567 | biostudies-arrayexpress
TranscriptomicsBrain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases
The neuronal ceroid lipofuscinoses (NCL) are a group of childhood inherited neurodegenerative disorders characterized by blindness, early dementia and pronounced cortical atrophy. The similar pathological and clinical profiles of different forms of NCL suggest that common disease mechanisms may be i...
ORGANISM(S): Mus musculus 
2008-05-21 | E-MEXP-1333 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human joint tissue using multiple biopsies taken from the same knee
Analysis of intra- and inter variation using multiple biopsies taken from the same knee. The biopsies were obtained from thirteen different patients; seven by orthopedic surgery and six by rheumatic arthroscopy. Orthopedic samples (patients 1-7 Three synovial tissue specimens were obtained from ran...
ORGANISM(S): Homo sapiens 
2005-06-22 | E-MEXP-367 | biostudies-arrayexpress
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