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TranscriptomicsMCL1 is deregulated in subgroups of diffuse large B-cell lymphoma
MCL1 is an anti-apoptotic member of the BCL2 family that is deregulated in various solid and hematological malignancies. However, its role in the molecular pathogenesis of diffuse large B-cell lymphoma (DLBCL) is unclear. We analyzed gene expression profiling data from 350 DLBCL patient samples and ...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-43272 | biostudies-arrayexpress
TranscriptomicsMALT1 protease activity controls the expression of inflammatory genes in keratinocytes upon Zymosan stimulation
The protease activity of the paracaspase MALT1 plays an important role in antigen receptor-mediated lymphocyte activation by controlling the activity of the transcription factor NF-kB and is thus essential for the expression of inflammatory target genes. MALT1 is not only present in cells of the hem...
ORGANISM(S): Homo sapiens 
2015-10-24 | E-GEOD-74297 | biostudies-arrayexpress
UnknownMalt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.
Not available
S-EPMC3167514 | biostudies-literature
UnknownCorrespondence: T cells are compromised in tetracycline transactivator transgenic mice.
Not available
S-EPMC5864203 | biostudies-literature
UnknownThe Atypical Inhibitor of NF-κB, IκBζ, Controls Macrophage Interleukin-10 Expression.
Not available
S-EPMC4933459 | biostudies-literature
UnknownIκBζ is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes.
Not available
S-EPMC6176600 | biostudies-literature
UnknownLNS-8801 as a therapeutic agent for aggressive lymphomas: ROS-induced cytotoxicity and synergy with existing therapies.
Not available
S-EPMC12268040 | biostudies-literature
TranscriptomicsEssential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein 1 (MALT1) is a proto-oncogene that contributes to tumorigenesis in diffuse larg...
ORGANISM(S): Homo sapiens 
2012-09-20 | E-GEOD-41034 | biostudies-arrayexpress
UnknownMonoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interface.
Not available
S-EPMC3747146 | biostudies-literature
UnknownThe CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis.
Not available
S-EPMC7598068 | biostudies-literature
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