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TranscriptomicsPF4-Cre mediated deletion of SRF in murine megakaryocytes.
Srf is a MADS-box transcription factor that is critical for muscle differentiation. Its function in hematopoiesis has not yet been revealed. Mkl1, a cofactor of Srf, is part of the t(1;22) translocation in acute megakaryoblastic leukemia, and plays a critical role in megakaryopoiesis. In order to te...
ORGANISM(S): Mus musculus 
2010-07-13 | E-GEOD-21859 | biostudies-arrayexpress
TranscriptomicsSRSF2 mutations impair hematopoiesis and alter exon recognition
Mutations within genes encoding spliceosomal proteins are the most common class of mutations in patients with myelodysplastic syndromes, yet it is currently not well understood how these mutations impact hematopoiesis or RNA splicing. Here we report that mutations affecting the splicing factor SRSF2...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-65349 | biostudies-arrayexpress
UnknownAdvancing biological understanding of cellular senescence with computational multiomics.
Not available
S-EPMC12916282 | biostudies-literature
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