Hall Laurence L

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Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on p53 status.

Not available

S-EPMC3164246 | biostudies-literature

Jarid2 regulates hematopoietic stem cell function by acting with Polycomb Repressive Complex 2

Polycomb Repressive Complex 2 (PRC2) has been shown to play a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is target...

ORGANISM(S): Mus musculus

2015-04-02 | E-GEOD-60808 | biostudies-arrayexpress

Transcription profiling of 5 strains of rat: WKY, spontaneously hypertensive rat (SHR) and 3 reciprocal congenic strains (WconSA, SconSA and SISA)

5 strains of rat, WKY, spontaneously hypertensive rat (SHR) and 3 reciprocal congenic strains (WconSA, SconSA and SISA) were used to generate expression data across the genome using the Affymetrix rat genome chip set comprising the 230 A and 230 B chips. 5 animals from each strain were used. Express...

ORGANISM(S): Rattus norvegicus

2007-04-16 | E-TABM-45 | biostudies-arrayexpress

Aged animals generate a robust immune response against swine origin 2009 pandemic H1N1 influenza A virus

In June 2009, the World Health Organization declared the first influenza pandemic of the 21st century, due to the emergence and rapid spread of new swine origin H1N1 influenza A virus. In contrast to seasonal influenza infections, which typically cause morbidity and mortality in the elderly, this vi...

ORGANISM(S): Macaca mulatta

2012-06-05 | E-GEOD-38502 | biostudies-arrayexpress

Interleukin-27 priming of T cells controls Interleukin-17-production in trans via induction of Programmed cell death ligand 1

Interleukin (IL)-27 is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27 might exert its immunosuppressive effect, we analyzed genes in T cells rapidly induced by IL-27. We found that IL-27 priming of naïve T cells upregu...

ORGANISM(S): Mus musculus

2012-06-30 | E-GEOD-38375 | biostudies-arrayexpress

Computationally restoring the potency of a clinical antibody against Omicron.

Not available

S-EPMC11111397 | biostudies-literature

Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK 'Alert Level 4' phase of the B-MaP-C study.

Not available

S-EPMC7993073 | biostudies-literature

Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic: outcomes from the B-MaP-C study.

Not available

S-EPMC10068712 | biostudies-literature

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.