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TranscriptomicsMicroarray study to understand acquired resistance to EGFR-targeted therapy in lung cancer
Activating mutations of EGFR have been characterized as important mechanisms for carcinogenesis in a subset of EGFR-dependent non-small cell lung cancers (NSCLC). EGFR tyrosine kinase inhibitors (TKI), such as erlotinib and gefitinib, have dramatic clinical effects on EGFR-addicted lung cancers and ...
ORGANISM(S): Homo sapiens 
2012-05-29 | E-GEOD-38310 | biostudies-arrayexpress
TranscriptomicsPIAS3 induction of apoptosis in non-small cell lung cancer cells is p53-independent and has STAT3-independent mediator.
Protein inhibitor of activated STAT3 (PIAS3) is an endogenous inhibitor of STAT3 that negatively regulates STAT3 transcriptional activity and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. In the present study we sought to determine if ...
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42979 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of generated Erlotinib-resistant (ER) cell lines
Targeted therapies have provided advantages to cancer patients, but these therapies are limited by differential responses and developed resistance. To discover mechanisms of resistance, we developed drug-resistant cell lines and have their gene expressions profiled and compared. HCC827 cells, which ...
ORGANISM(S): Homo sapiens 
2012-06-15 | E-GEOD-38121 | biostudies-arrayexpress
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