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GenomicsGenome-wide analysis of histone modifications in latently HIV-1 infected T cells
The epigenetic mechanisms established by histone modifications may affect the transcriptional silencing of HIV-1 and viral latency. A systematic epigenome profiling could be applicable to develop new epigenetic diagnostic markers for detecting HIV-1 latency. In this study, histone modification prof...
ORGANISM(S): Homo sapiens 
2014-06-06 | E-GEOD-58247 | biostudies-arrayexpress
TranscriptomicsFunctional analysis of KAI1
We sequenced mRNA from mouse EML cell line under Kai1 knockdown or Kai1 overexpressing condition. KAI1 belongs to tetraspanin superfamily and is known as suppressor of tumor metastasis. Examination of mRNA levels in wildtype (WT) and KAI1 knockdown EML cells were generated by deep sequencing, in dup...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-56867 | biostudies-arrayexpress
ProteomicsRibonuclease κ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules
Circular RNAs (circRNAs) accumulate with age, but their functional impact on aging remains elusive. In this study, we reveal a mechanism by which ribonuclease κ (RNASEK) prevents age-dependent circRNA accumulation by promoting its degradation. Through a genetic screen targeting ribonucleases, we ide...
ORGANISM(S): Caenorhabditis Elegans 
2026-01-15 | PXD073097 |
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