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The incidence of CI-AKI varies from 5% to 20% among hospitalized patients. However, research on the pathophysiological mechanism and biomarkers of CI-AKI has not been deep so far, especially research with LC-MS/MS methods. MS has brought proteomics research into the modern era and continues to be th...
ORGANISM(S): Homo Sapiens 
2021-02-21 | PXD024271 |
Although well characterized as a transcriptional activator, androgen receptor (AR) can also function as a direct transcriptional repressor in prostate cancer cells. The major targets of the AR repressive function are genes mediating DNA synthesis. In this study, we found that AR was recruited to th...
ORGANISM(S): Homo sapiens 
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014836 | Pride
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