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TranscriptomicsAn RNASeq normal tissue atlas for mouse and rat
The function of a gene is closely connected to its expression specificity across tissues and cell types. RNA-Seq is a powerful quantitative tool to explore genome wide expression. The aim of the present study is to provide a comprehensive RNA-Seq dataset across the same 13 tissues for mouse and rat,...
ORGANISM(S): Rattus norvegicus 
2017-10-25 | E-MTAB-6081 | biostudies-arrayexpress
MetabolomicsEfficacy of Zhuyu Pill Intervention in a Cholestasis Rat Model: Mutual Effects on Fecal Metabolism and Microbial Diversity

Cholestasis is a clinical condition resulting from the impairment of bile flow. Currently, patients with cholestasis still face several barriers in seeking diagnosis and treatment. Zhuyu Pill (ZYP) is an ancient classic formula of the Coptis-Evodia herb couples (CEHC), and has been used for chole...

2022-05-30 | MTBLS2721 | MetaboLights
TranscriptomicsExpression data from kidneys of rats with and without cisplatin treatment
We investigated an acute kidney injury (AKI) model in rats induced by cisplatin (Cp) administration. The cisplatin is widely used since its biochemical and histopathological characteristics are representative of drug-induced AKI in humans. Male Wistar rats were dosed once ip with 0, 1 and 3 mg/kg ...
ORGANISM(S): Rattus norvegicus 
2016-08-23 | E-GEOD-85957 | biostudies-arrayexpress
MetabolomicsDetermination and comparison of SCFAs in serum and colon content samples: Alzheimer's disease rat as a case study (Method validation)

SCFAs are the main microbial fermentation products from dietary fibers in colon and play a key role in keeping healthy in the whole-body. However, differences of SCFAs concentration in the serum and colon samples collected from rats had attracted few attentions. Here, we optimized the extract and...

2020-11-24 | MTBLS2146 | MetaboLights
TranscriptomicsTranscriptional Profiling of rat hypothalamic response to TCDD
In many mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as lethal weight loss as a result of severe and persistent hypophagia. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), which exerts its toxic effects through the ar...
ORGANISM(S): Rattus norvegicus 
2014-12-23 | E-GEOD-61039 | biostudies-arrayexpress
MetabolomicsDetermination and comparison of SCFAs in serum and colon content samples: Alzheimer's disease rat as a case study (SCFA serum and colon content determination)

SCFAs are the main microbial fermentation products from dietary fibers in colon and play a key role in keeping healthy in the whole-body. However, differences of SCFAs concentration in the serum and colon samples collected from rats had attracted few attentions. Here, we optimized the extract and...

2020-11-24 | MTBLS2088 | MetaboLights
TranscriptomicsMicro-RNAs in Adult Rat Liver are Refractory to 19 Hours Dioxin Exposure
Dioxin-like chemicals are well-known for their ability to upregulate expression of numerous genes via the AH receptor (AHR). However, recent transcriptomic analyses in several laboratories indicate that dioxin-like chemicals or AHR genotype itself also can downregulate levels of mRNAs encoded by nu...
ORGANISM(S): Rattus norvegicus 
2007-08-15 | E-GEOD-8467 | biostudies-arrayexpress
TranscriptomicsCross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (miRNA)
In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular ...
ORGANISM(S): Rattus norvegicus 
2014-08-18 | E-GEOD-53083 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat liver display strain-specific, hereditary and AHR-Dependent Components
Background; The rat is a major model organism in toxicogenomics and pharmacogenomics, and the use of steady-state hepatic mRNA levels to predict and understand drug toxicity and mechanism is well-established. Surprisingly, the inter- and intra-strain variability of rat mRNA expression has not been e...
ORGANISM(S): Rattus norvegicus 
2009-11-28 | E-GEOD-10448 | biostudies-arrayexpress
ProteomicsCross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (protein)
In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular ...
ORGANISM(S): Rattus norvegicus 
2014-08-18 | E-GEOD-53084 | biostudies-arrayexpress
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