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TranscriptomicsThe genetic framework of the Drosophila piRNA pathway
The animal piRNA pathway is a small RNA silencing system that acts in gonads and protects the genome against the deleterious influence of transposons. A major bottleneck in the field is the lack of comprehensive knowledge of the factors and molecular processes that constitute this pathway. We conduc...
ORGANISM(S): Drosophila melanogaster 
2013-05-10 | E-GEOD-45894 | biostudies-arrayexpress
TranscriptomicsNovel piRNA Pathway Components Identified Among the Class of TUDOR Domain Containing Proteins
PIWI proteins and their bound piRNAs form the core of a gonad specific small RNA silencing pathway in animals that protects the genome against the deleterious activity of transposable elements. Recent studies linked the piRNA pathway to TUDOR biology, where TUDOR domains of various proteins recogniz...
ORGANISM(S): Drosophila melanogaster 
2011-08-16 | E-GEOD-30955 | biostudies-arrayexpress
TranscriptomicsThe Rhino-Deadlock-Cutoff complex licenses non-canonical transcription of dual-strand piRNA clusters in Drosophila
Argonaute proteins of the PIWI clade are central to transposon silencing in animal gonads. Their target specificity is defined by 22-30nt PIWI interacting RNAs (piRNAs), which mostly originate from discrete genomic loci termed piRNA clusters. Here we show that the RDC complex composed of Rhino, Dead...
ORGANISM(S): Drosophila melanogaster 
2014-06-08 | E-GEOD-55824 | biostudies-arrayexpress
TranscriptomicsThe exon junction complex is required for definition and excision of neighboring introns in Drosophila
Splicing of pre-mRNAs results in the deposition of the exon junction complex (EJC) upstream of exon-exon boundaries. The EJC plays crucial post-splicing roles in export, translation, localization and nonsense-mediated decay of mRNAs. It also aids faithful splicing of pre-mRNAs containing large intro...
ORGANISM(S): Drosophila melanogaster 
2014-12-04 | E-GEOD-58830 | biostudies-arrayexpress
TranscriptomicspiRNA-guided slicing specifies transcripts for Zucchini dependent, phased piRNA biogenesis
PIWI-clade Argonaute proteins repress transposable elements in animal gonads. Their sequence specificity is conferred via bound ~23-30nt long piRNAs, which are processed from single stranded precursor RNAs. How transcripts are specified as precursors and processed into stereotypical piRNA population...
ORGANISM(S): Drosophila melanogaster 
2015-06-07 | E-GEOD-64802 | biostudies-arrayexpress
TranscriptomicsA genome-scale shRNA resource for transgenic RNAi in Drosophila
Existing transgenic RNAi resources in Drosophila utilize the expression of long double stranded hairpin RNAs and are powerful tools for the identification and characterization of genes involved in various processes. However, they are ineffective to knockdown genes during oogenesis, an important mode...
ORGANISM(S): Drosophila melanogaster 
2011-03-26 | E-GEOD-27039 | biostudies-arrayexpress
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