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TranscriptomicsTranscription profiling by array of mouse C2C12 muscle cells overexpressing PGC-1alpha, PGC-1beta or GFP to investigate differential expression of TNFalpha-induced genes
Differentiated C2C12 cells adenovirally overexpressing either PGC-1alpha or PGC-1beta or GFP as control were treated with TNFalpha for 2h or left untreated. NF-kappaB- and stress-depedent gene expression was determined by a customized array.
ORGANISM(S): Mus musculus 
2012-12-14 | E-MEXP-3676 | biostudies-arrayexpress
GenomicsTranscriptional network analysis in muscle reveals AP-1 as a partner of PGC-1M-NM-1 in the regulation of the hypoxic gene program
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-06-16 | E-GEOD-51191 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Ncor1 muscle-specific knockout and PGC-1alpha muscle-specific transgenic skeletal muscle
In the present study we have studied the mechanistic and functional aspects of NCoR1 function in mouse skeletal muscle. NCoR1 muscle-specific knockout mice exhibited an increased oxidative metabolism. Global gene expression analysis revealed a high overlap between the effects of NCoR1 deletion and p...
ORGANISM(S): Mus musculus 
2013-01-08 | E-GEOD-40439 | biostudies-arrayexpress
TranscriptomicsTranscriptional network analysis in muscle reveals AP-1 as a partner of PGC-1M-NM-1 in the regulation of the hypoxic gene program [microarray: kD_AP1]
Skeletal muscle tissue shows an extraordinary cellular plasticity, but the underlying molecular mechanisms are still poorly understood. Here we use a combination of experimental and computational approaches to unravel the complex transcriptional network of muscle cell plasticity centered on the pero...
ORGANISM(S): Mus musculus 
2014-06-16 | E-GEOD-51190 | biostudies-arrayexpress
TranscriptomicsTranscriptional network analysis in muscle reveals AP-1 as a partner of PGC-1M-NM-1 in the regulation of the hypoxic gene program [microarray: PGC1a_vs_GFP]
Skeletal muscle tissue shows an extraordinary cellular plasticity, but the underlying molecular mechanisms are still poorly understood. Here we use a combination of experimental and computational approaches to unravel the complex transcriptional network of muscle cell plasticity centered on the pero...
ORGANISM(S): Mus musculus 
2014-06-16 | E-GEOD-51189 | biostudies-arrayexpress
GenomicsTranscriptional network analysis in muscle reveals AP-1 as a partner of PGC-1M-NM-1 in the regulation of the hypoxic gene program [ChIP-Seq]
Skeletal muscle tissue shows an extraordinary cellular plasticity, but the underlying molecular mechanisms are still poorly understood. Here we use a combination of experimental and computational approaches to unravel the complex transcriptional network of muscle cell plasticity centered on the pero...
ORGANISM(S): Mus musculus 
2014-06-16 | E-GEOD-51178 | biostudies-arrayexpress
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