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TranscriptomicsNOD2 and desease associated variant NOD2-L1007fsinsC dependent genomewide transcriptional regulation in stable Flp-In HEK cells
NOD2 is an intracellular receptor for the bacterial cell wall component muramyl dipeptide (MDP) and variants of NOD2 are associated with chronic inflammatory diseases of barrier organs e.g. Crohn disease, asthma and atopic eczema. It is known that activation of NOD2 induces a variety of inflammatory...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-22611 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Bone-Marrow-Derived-Macrophages (5 days of culture) in a backcross population of LEW and WKY
WKY and LEW strains have been widely studied for their differential susceptibility to experimental glomerulonephritis. In particular these strains show strong variations in the macrophage activation. This dataset measures expression of macrophages in backcross population of WKY DC and LEW rats and ...
ORGANISM(S): Rattus norvegicus 
2014-08-31 | E-MTAB-2719 | biostudies-arrayexpress
TranscriptomicsMEK5 is Activated by Shear Stress, Activates ERK5 And Induces KLF4 To Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells
MEK5 is activated by shear stress in large vessel endothelial cells (ECs) and contributes to the suppression of pro-inflammatory changes in the arterial wall. We used microarray analyses of total RNA from MEK5/CA-transduced HDMECs compared to LacZ control-transduced HDMECs to identify distinct class...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-25145 | biostudies-arrayexpress
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