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TranscriptomicsTranscriptome profile of human dermal macrophages and monocyte-derived macrophages
DC, monocyte and macrophage networks are evolutionarily conserved but the distinct subsets have been difficult to distinguish due to shared overlapping phenotypic markers between the cells. Using transcriptome microarray profiling of human and mouse mononuclear phagocyte subsets, we have distinguish...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-60317 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of mouse lung dendritic cell subsets and macrophages.
Dendritic cell (DC) are critical initiators and regulators of immunity to pathogens, vaccines, tumors and tolerance to self. Mouse and human dendritic cells (DCs) are comprised of functionally specialized subsets, but precise interspecies correlation is currently incomplete and hampers the full tra...
ORGANISM(S): Mus musculus 
2013-05-29 | E-GEOD-46680 | biostudies-arrayexpress
TranscriptomicsHuman fetal liver, skin and kidney single cell transcriptome data
This is a droplet-based single cell transcriptome data set from 13 human fetal livers (6-18 PCW) and 8 skin and kidney samples (6-12 PCW). It includes 199,642 cells with a mean detected gene number of 3000.
ORGANISM(S): Homo sapiens 
2019-10-11 | E-MTAB-7407 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of mouse and human monocyte and dendritic cell subsets (human data)
Dendritic cells (DCs) are critical in mediating immunity to pathogens, vaccines, tumors and tolerance to self. Significant progress has been made in the study of DC subsets in murine models but the translation of these findings to human DC immunobiology has not been fully realized. Murine splenic C...
ORGANISM(S): Homo sapiens 
2012-07-11 | E-GEOD-35457 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of mouse and human monocyte and dendritic cell subsets (mouse data)
Dendritic cells (DCs) are critical in mediating immunity to pathogens, vaccines, tumors and tolerance to self. Significant progress has been made in the study of DC subsets in murine models but the translation of these findings to human DC immunobiology has not been fully realized. Murine splenic C...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-35458 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics of fetal skin
Spatial organization of different cell types within prenatal skin across various anatomical sites is not well understood. To address this, here we have generated spatial transcriptomics data from prenatal facial and abdominal skin obtained from a donor at 10 post conception weeks. This in combinatio...
ORGANISM(S): Homo sapiens 
2024-06-04 | E-MTAB-13024 | biostudies-arrayexpress
TranscriptomicsMultiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma - Spatial Transcriptomics - 10X Visium
Our understanding of how human skin cells differ according to anatomical site and tumour formation is limited. To address this we have created a multi-scale spatial atlas of healthy skin and basal cell carcinoma (BCC), incorporating in vivo optical coherence tomography, single cell RNA sequencing, s...
ORGANISM(S): Homo sapiens 
2023-12-22 | E-MTAB-13085 | biostudies-arrayexpress
Transcriptomicssingle-cell RNA-seq of of dermal fibroblasts
Dermal fibroblasts from human, rhesus macaque, mouse and rat, stimulated with dsRNA (poly I:C) in a time course of 0,2,4 and 8 hours, profiled using the Smart-seq2 protocol.
The innate immune response - the expression programme that is initiated once a pathogen is sensed - is known to be variable...
ORGANISM(S): Macaca mulatta 
2018-07-06 | E-MTAB-5920 | biostudies-arrayexpress
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - 10x data
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. RNA-seq was done usin...
ORGANISM(S): Homo sapiens 
2018-10-02 | E-MTAB-6701 | biostudies-arrayexpress
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - Smartseq 2 data
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. This part contains RN...
ORGANISM(S): Homo sapiens 
2019-08-21 | E-MTAB-6678 | biostudies-arrayexpress
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