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ProteomicsCullin-RING ligases target substrates with geometrically optimized catalytic partners
Cullin-RING ubiquitin ligases (CRLs) control the degradation of a wide landscape of human proteins in combination with ubiquitin-carrying enzymes (UCEs). CRL expansion during evolution is apparent, with a few dozen in yeast that function with a single UCE and as many as 300 in humans that function w...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD043523 | Pride
Ubiquitylation Cullin-ring ligase 
ProteomicsInterconversion between anticipatory and active GID E3 ubiquitin ligase conformations via metabolically-driven substrate receptor assembly
Cells respond to environmental changes by toggling metabolic pathways, preparing for homeostasis, and anticipating future stresses. For example, in Saccharomyces cerevisiae starvation-induced gluconeogenesis is terminated upon glucose availability, a process that involves the multiprotein E3 ligase,...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-10-19 | PXD015396 | Pride
E3 ubiquitin ligase Lc-ms/ms 
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