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MetabolomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The regulation of gene expression in response to nutrient availability is fundamental to the genotype-phenotype relationship. The metabolic-genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metaboli...
2016-12-16 | MTBLS168 | MetaboLights
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsGene Expression differences in Hepatic Parenchyma and Portal Tracts in Hepatitis C Virus Infected Subjects with High and Low Fibrosis
Background & Aims: Chronic hepatitis C virus (HCV) infection is complicated by hepatic fibrosis. Hypothesizing that fibrogenic signals may originate in cells susceptible to HCV infection, gene expression of hepatocytes was analyzed from persons with chronic HCV at different stages of liver fibrosi...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-33650 | biostudies-arrayexpress
UnknownPrevalence and predictors of urine culture contamination in primary care: A cross-sectional study.
Not available
S-EPMC10513105 | biostudies-literature
UnknownhVMAT2: A Target of Individualized Medication for Parkinson's Disease.
Not available
S-EPMC4965405 | biostudies-literature
UnknownClinical factors and diagnoses associated with inappropriate urine culture ordering in primary care.
Not available
S-EPMC12825956 | biostudies-literature
UnknownValidating Use of Electronic Health Data to Identify Patients with Urinary Tract Infections in Outpatient Settings.
Not available
S-EPMC7558992 | biostudies-literature
ProteomicsA microbial supply chain for production of anti-cancer drug vinblastine
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine. As MIAs are difficult to chemically synthesize, the world’s supply chain for vinblastine relie...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-21 | PXD025067 | Pride
Yeast synthetic biology Monoterpene indole alkaloids Natural products 
TranscriptomicsEffects of human skeletal muscle fibroblast and stem cell media on cultured rat motor neuron cells
The study was designed to compare whether and how muscle fibroblasts (FIB) and muscle stem cells (MYO) interact with motor neurons. Moreover, we aimed to investigate whether muscle cells, isolated from lifelong exercisers, exerted a protective and supportive effect on motor neurons. These object...
ORGANISM(S): Rattus norvegicus 
2026-02-21 | E-MTAB-14399 | biostudies-arrayexpress
UnknownImpact of Complete Revascularization in the ISCHEMIA Trial.
Not available
S-EPMC10529674 | biostudies-literature
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