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TranscriptomicsTranscription profiling of mouse skin carcinogenesis in FVB/N and Tg.Ac mice
Female FVB/N and Tg.Ac (hemizygotes) mice 3-5 weeks of age were purchased from Harlan UK and Taconic UK, respectively. The mice were contained in an isolator and maintained at 19C with 50% relative humidity and a 12-hour light-dark cycle. Following a 1 week acclimatisation period the dorsal skin o...
ORGANISM(S): Mus musculus 
2005-10-01 | E-MEXP-188 | biostudies-arrayexpress
TranscriptomicsCrizotinib inhibits metabolic inactivation of gemcitabine in ortothopic pancreatic tumors derived from primary cells with c-Met overexpression
Pancreatic ductal adenocarcinoma (PDAC) remains a major unsolved health problem. Most drugs that pass preclinical tests fail in these patients, emphasizing the need of appropriate preclinical models to test novel anticancer strategies. We developed four orthotopic mouse models employing primary huma...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-44587 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse inbred strains (8) on Affymetrix exon specific array
Expression profiling of 8 mouse inbred strains on Affymetrix exon specific array
ORGANISM(S): Mus musculus 
2009-06-04 | E-MTAB-86 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hippocampus, lung and liver for expression quanitative trait analysis
A proportion of the genetic variants underlying complex phenotypes do so through their effects on gene expression, so an important challenge in complex trait analysis is to discover the genetic basis for the variation in transcript abundance. So far, the potential of mapping both quantitative trait ...
ORGANISM(S): Mus musculus 
2009-10-22 | E-MTAB-88 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat kidney samples following treatment with the corticosteroid methylprednisolone over several time intervals
Summary: To identify distinct temporal patterns of mRNA expression in the kidney of rats following a bolus dose of the corticosteroid methylprednisolone. Hypothesis: That prednisone pharmacodynamics can be derived from expression profiling data.
ORGANISM(S): Rattus norvegicus 
2007-09-13 | E-GEOD-1721 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of four mouse tissues following acute caloric restriction
Multi-tissue transcriptional response following acute caloric restriction in mice.
ORGANISM(S): Mus musculus 
2007-05-17 | E-MEXP-748 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skeletal muscles from young, old, and old calorie restricted C57BL/6NHsd mice to investigate age-related changes in the transcriptional profile
We investigated age-related changes in the transcriptional profile of skeletal muscle in 5 month old (young) and 25 month old (old) C57BL/6NHsd mice using high density oligonucleotide arrays (22,690 transcripts probed). We identified 712 transcripts that are differentially expressed in young (5 mon...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-6323 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chord and interstitial regions of rat testes at gestational day 19 treated in utero with dibutylphthalate (DBP)
An experiment was performed to assess the effects on rats of in utero dibutylphthalate (DBP)-treatment on the transcriptome of whole fetal testes at gestational day 19.
ORGANISM(S): Rattus norvegicus 
2007-04-05 | E-TABM-201 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of rat heart tissue treated with saline or doxorubicin to identify molecular mechanisms of doxorubicin cardiac toxicity
Doxorubicin induces cardiomypathy in oncology patients. This study is aimed at identifying molecular mechanisms of doxorubicin cardiac toxicity in rats. Transcription profiling of heart tissue of rats treated with saline or doxorubicin 1, 2 or 3 mg/kg/week by iv once per week for 2, 4 or 6 weeks. So...
ORGANISM(S): Rattus norvegicus 
2012-07-01 | E-MTAB-1168 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of two protein phosphatases(ppm2 and ppm5) knockouts in Plasmodium berghei to study their role in the parasite's sexual development
To identify protein phosphatases (PP) that are essential during asexual blood stage development in Plasmodium berghei, we attempted systematic deletion of the 30 P. berghei PP genes using double homologous recombination. Of these, we performed strand-specific RNA-sequencing (RNA-Seq) analysis for 2...
ORGANISM(S): Plasmodium berghei 
2014-04-16 | E-MTAB-2215 | biostudies-arrayexpress
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