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ModelsRegan2022 - Mechanosensitive EMT model with autocrine TGFbeta signaling
This model is an expansion of the Regan2022 - Mechanosensitive EMT model (MODEL2208050001); it includes a TGFβ signaling module and autocrine signaling in mesenchymal cells. The expanded 150-node (630 link) modular model undergoes EMT triggered by biomechanical and growth signaling crosstalk, or by ...
2023-12-13 | MODEL2208050002 | BioModels
ModelsRegan2022 - Mechanosensitive EMT model
This file contains a 136-node modular Boolean network model of EMT triggered by biomechanical and growth signaling crosstalk, linked to a published network of epithelial contact inhibition, proliferation, and apoptosis (MODEL2006170001). This model reproduces the ability of the core EMT transcriptio...
2023-12-13 | MODEL2208050001 | BioModels
ModelsSizek2023 - Mitochondrial Dysfunction-Associated Senescence (MiDAS) with cell cycle and apoptosis
This 133-node Boolean regulatory network model reproduces mitochondrial dynamics during cell cycle progression (hyper-fusion at the G1/S boundary, fission in mitosis), apoptosis (fission and dysfunction) and glucose starvation (reversible hyper-fusion), as well as MiDAS in response to SIRT3 knockdow...
2024-08-26 | MODEL2312140001 | BioModels
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