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TranscriptomicsAnti-inflammatory compounds in SCI
A screen of 5 anti-inflammatory compounds for their effects in explanted, cultured rat spinal cord slices. All injured (explanted) cords are cultured for 4 hrs.
ORGANISM(S): Rattus norvegicus 
2010-06-05 | E-GEOD-633 | biostudies-arrayexpress
TranscriptomicsSelective loss of 5hmC links to A-T Purkinje cell vulnerability
This SuperSeries is composed of the SubSeries listed below. The neurodegenerative disease known as ataxia-telangiectasia (A-T) is caused by the absence of the ATM (A-T mutated) protein. A long-standing mystery surrounding A-T is why cerebellar Purkinje cells (PCs) appear uniquely vulnerable to ATM-...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-61169 | biostudies-arrayexpress
TranscriptomicsNMLF response to spinal cord injury in Zebrafish
The study was designed to identify genes regulated after spinal transection that might contribute to regenerative growth of neurons projecting from the NMLF in Zebrafish. Zebrafish were injured by surgical transection of the spinal cord at 1 mm caudal to the brainstem-spinal cord junction (Injured)....
ORGANISM(S): Danio rerio 
2011-12-01 | E-GEOD-28470 | biostudies-arrayexpress
TranscriptomicsB lymphoma from TRAF3-deficient mice
Spleen samples with B lymphoma from TRAF3 knockout mice compared with littermate controls 3 lymphoma samples, 4 control samples
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-48818 | biostudies-arrayexpress
TranscriptomicsIdentification of differentiation status of human embryonic stem cell cultures.
Two stages of culture were tested. ESC is the pluripotent stage expressing SSEA4 and Oct4 but not SSEA1. NSC is a neural-committed stage expressing Nestin but not beta-tubulin. Three cell lines were tested: H1, HSF1, and HSF6. One sample was assayed from each cell line at each stage of culture. C...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-15206 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of developing mouse cortex reveals regulation of ribosomal protein mRNAs throughout development
Neocortical development is spatiotemporally regulated by exogenous factors, but the mechanism regulating timed specificity of neocortical mRNA translation is unknown. We find that active mRNA translation sites (polysomes) contain ribosomal protein subsets that undergo dynamic spatiotemporal rearrang...
ORGANISM(S): Mus musculus 
2015-06-26 | E-GEOD-61751 | biostudies-arrayexpress
TranscriptomicsEZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia
The symptoms of ataxia-telangiectasia (A-T) include a progressive neurodegeneration caused by ATM protein deficiency. We previously found that nuclear accumulation of histone deacetylase-4, HDAC4, contributes to this degeneration; we now report that increased histone H3K27 trimethylation (H3K27me3) ...
ORGANISM(S): Mus musculus 
2013-10-25 | E-GEOD-50951 | biostudies-arrayexpress
TranscriptomicsAtaxia-telangiectasia cerebellar cortex expression
Cerebellar cortex expression in ataxia-telangiectasia patients and normal controls. The neurodegenerative disease known as ataxia-telangiectasia (A-T) is caused by the absence of the ATM (A-T mutated) protein. A long-standing mystery surrounding A-T is why cerebellar Purkinje cells (PCs) appear uni...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-61019 | biostudies-arrayexpress
TranscriptomicsDanio spinal cord injury
Adult zebrafish have the ability to recover from spinal cord injury and exhibit re-growth of descending axons from the brainstem to the spinal cord. We performed gene expression analysis using microarray to find damage-induced genes after spinal cord injury, which shows that Sox11b mRNA is up-regula...
ORGANISM(S): Danio rerio 
2010-10-19 | E-GEOD-20460 | biostudies-arrayexpress
TranscriptomicsIsolation of a Novel Rat Neural Progenitor Clone that Expresses Dlx Family Transcription Factors and Gives Rise to Functional GABAergic Neurons in Culture
GABAergic interneurons are lost in conditions including epilepsy and CNS injury, but there are few culture models available to study their function. Towards the goal of obtaining renewable sources of GABAergic neurons, we used the molecular profile of a functionally-incomplete GABAergic precursor c...
ORGANISM(S): Rattus norvegicus 
2011-11-09 | E-GEOD-31635 | biostudies-arrayexpress
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