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TranscriptomicsEvaluation of quantitative miRNA gene expression platforms - custom microRNA GeneChip
MicroRNA microarray expression dataset used to develop novel and robust quality metrics to objectively assess platform performance of very different technologies. The HsMir v1s520779F custom array is primarly based on the commercially available Affymetrix microRNA microarray version 2.0 (Affymetrix ...
ORGANISM(S): Homo sapiens 
2013-08-09 | E-GEOD-49661 | biostudies-arrayexpress
TranscriptomicsMRNA expression data from human breast cancer cell lines after demethylation treatment.
The contribution of aberrant DNA methylation and the downstream effects in tumorogenesis through silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations can be reversed, we investigated the effects of the epigenetic therapy in breast cancer ...
ORGANISM(S): Homo sapiens 
2012-01-24 | E-GEOD-28968 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression data from human breast cancer cell lines after demethylation treatment.
The contribution of aberrant DNA methylation and the downstream effects in tumorogenesis through silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations can be reversed, we investigated the effects of the epigenetic therapy in breast cancer ...
ORGANISM(S): Homo sapiens 
2012-01-24 | E-GEOD-28969 | biostudies-arrayexpress
TranscriptomicsInfluence of RNA Labeling on Expression Profiling of MicroRNAs
Several technical parameters are now being optimized for microRNA expression profiling experiments, but the finite amount of total RNA available continues to bottleneck clinical investigations. We used microarrays to determine the influence of the labeling reagent on total RNA requirements and data ...
ORGANISM(S): synthetic construct 
2012-05-21 | E-GEOD-30045 | biostudies-arrayexpress
TranscriptomicsExpression data from pure/mixed brain, liver and lung to test feasability and sensitivity of statistical deconvolution
Tissues are often made up of multiple cell-types. Blood, for example, contains many different cell-types, each with its own functional attributes and molecular signature. In humans, because of its accessibility and immune functionality, blood cells have been used as a source for RNA-based biomarkers...
ORGANISM(S): Rattus norvegicus 
2010-04-06 | E-GEOD-19830 | biostudies-arrayexpress
TranscriptomicsGene expression data of whole blood of systemic juvenile idiopathic arthritis (SJIA) patients treated with canakinumab or placebo and age matched healthy controls
Canakinumab is a human anti-interleukin-1 beta (IL-1 beta) monoclonal antibody neutralizing IL-1 beta. Systemic juvenile idiopathic arthritis (SJIA) is a rare, multigenic, autoinflammatory disease of unknown etiology characterized by chronic arthritis; intermittent high-spiking fever, rash, and elev...
ORGANISM(S): Homo sapiens 
2016-04-29 | E-GEOD-80060 | biostudies-arrayexpress
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