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ProteomicsIntracellular Iron Accumulation Facilitates Mycobacterial Infection in Old Mouse Macrophages
Aging has a significant impact on the immune system, leading to a gradual decline in immune function and changes in the body's ability to respond to bacterial infections. Non-tuberculous mycobacteria (NTM), also known as atypical mycobacteria or environmental mycobacteria, are commonly found in soil...
ORGANISM(S): Mycobacterium avium Mus musculus (Mouse) Mycobacterium tuberculosis 
2024-05-24 | PXD045821 | Pride
Macrophages Iron Mycobacterium Aging 
ProteomicsThe ESX-4 type VII secretion system in required for efficient heme utilization by Mycobacterium tuberculosis
In this study our primary objective was to identify unknown components that are required of Mtb Hm acquisition. Herein, we show that the ancestral ESX-4 type VII secretion system (T7SS) which was thought to be inactive in Mtb is required for efficient Hm utilization. We also identified that the cult...
ORGANISM(S): Acyrthosiphon pisum (Pea aphid) 
2023-01-31 | PXD036081 | Pride
Type vii secretion Iron acquisition Mycobacterium tuberculosis Heme Channel protein Ppe Outer membrane Esx-4 
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