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TranscriptomicsTranscriptional profiling of a novel pro-angiogenic small molecule phthalimide neovascular factor 1 (PNF1)
We generated the transcriptional regulatory footprint of phthalimide neovascular factor 1 (PNF1)—a novel synthetic small molecule that exhibits significant in vitro endothelial potency and significant in vivo microvascular network expansion—by performing comparative microarray analysis on PNF1-stimu...
ORGANISM(S): Homo sapiens 
2009-07-17 | E-GEOD-17119 | biostudies-arrayexpress
Transcriptomicsp53 reactivation in liver tumors
We induced liver tumors by transforming liver progenitor cells (LPC) with retroviruses expressing oncogenic Ras coupled to tetracycline transactivator together with an inducible shRNA targeting p53. Transformed LPCs were orthotopical transplanted into recipient livers and after tumor onset mice wer...
ORGANISM(S): Mus musculus 
2013-11-11 | E-GEOD-52091 | biostudies-arrayexpress
TranscriptomicsA phase II study of adding the multikinase sorafenib to existing endocrine therapy in patients with metastatic ER-positive breast cancer.
Growth factor signaling and angiogenesis may promote endocrine-resistance in breast cancer and blocking these pathways can overcome resistance in preclinical models. We conducted a phase-II study of adding the VEGFR/Ras/Raf/MAPK inhibitor sorafenib to endocrine therapy in metastatic ER-positive bre...
ORGANISM(S): Homo sapiens 
2012-09-13 | E-GEOD-40837 | biostudies-arrayexpress
TranscriptomicsVibrio cholerae in human vomitus vs. human stool
Understanding gene expression by bacteria during the actual course of human infection may provide important insights into microbial pathogenesis. In this study, we evaluated the transcriptional profile of Vibrio cholerae, the causative agent of cholera, in clinical specimens from cholera patients. W...
ORGANISM(S): Vibrio cholerae 
2010-06-09 | E-GEOD-2775 | biostudies-arrayexpress
Genomicsena-DATASET-AMC-11-05-2015-14:58:16:693-185 - samples
The majority of neuroblastoma patients have tumors that initially respond to chemotherapy, but a large proportion of patients will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole genome sequencing of 23 paired diagnostic and relapsed neurobla...
EGAD00001001360 | EGA
GenomicsNeuroblastoma relapse trio series from the AMC
The majority of neuroblastoma patients have tumors that initially respond to chemotherapy, but a large proportion of patients will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole genome sequencing of 23 paired diagnostic and relapsed neurobla...
EGAS00001001183 | EGA
UnknownMulti-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
Not available
S-EPMC9179018 | biostudies-literature
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