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TranscriptomicsSalmon Macrophage early response to Aeromonas salmonicida
Aeromonas salmonicida is a fish pathogen that causes furunculosis. Virulent strains of this bacterium are able to infect salmonid macrophages and survive within them, although mechanisms favouring intracellular survival are not completely understood. It is known that A. salmonicida cultured in vivo ...
ORGANISM(S): Salmo salar 
2010-05-26 | E-GEOD-8526 | biostudies-arrayexpress
TranscriptomicsExpression data comparing KRas(G12D/+);CreT, R26(H1047R/+);KRas(G12D/+);CreT, and MMTV-Neu mouse mammary tumors
Breast Cancer (BC) has been associated with alterations in signaling through a number of growth factor and hormone regulated pathways. Mouse models for metastatic BC have been developed using oncoproteins that activate PI3K, Stat3 and Ras signaling. To determine the role of each pathway, we analyz...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-73073 | biostudies-arrayexpress
TranscriptomicsIQGAP1 Scaffold-Kinase Interaction Blockade Selectively Targets Ras-MAP Kinase Driven Tumors
MAPK scaffolds, such as IQGAP1, assemble pathway kinases together to effect signal transmission and disrupting scaffold function therefore offers a potentially orthogonal approach to MAPK cascade inhibition. Consistent with this possibility, we observed an IQGAP1 requirement in Ras-driven tumorigene...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-44967 | biostudies-arrayexpress
TranscriptomicsTwist1 Directly Regulates Genes That Promote Cell Proliferation and Migration in Developing Heart Valves
Twist1, a basic helix-loop-helix transcription factor, is expressed in mesenchymal precursor populations during embryogenesis and in metastatic cancer cells. In the developing heart, Twist1 is highly expressed in endocardial cushion (ECC) valve mesenchymal cells and is down regulated during valve d...
ORGANISM(S): Mus musculus 
2011-07-27 | E-GEOD-30953 | biostudies-arrayexpress
TranscriptomicsInactivation of the GacA response regulator in Pseudomonas fluorescens Pf-5 has far-reaching transcriptomic consequences
The GacS/GacA signal transduction system is a central regulator in Pseudomonas spp., including the biological control strain P. fluorescens Pf-5, in which GacS/GacA controls the production of secondary metabolites and exoenzymes that suppress plant pathogens. A whole genome oligonucleotide microarra...
ORGANISM(S): Pseudomonas fluorescens Pf-5 
2010-03-03 | E-GEOD-16898 | biostudies-arrayexpress
TranscriptomicsFC-IBC-02: A New in vitro-in vivo Model of Triple Negative Inflammatory Breast Cancer
Inflammatory breast cancer (IBC) is the most aggressive type of advanced breast cancer and is associated with a poor prognosis. We have developed a new model of IBC derivated from the pleural effusion of a 49-year-old woman with metastatic secondary IBC. FC-IBC02 tumor cells were isolated from the p...
ORGANISM(S): Homo sapiens 
2012-09-20 | E-GEOD-40464 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of Botrytis cinerea genes targeting plant cell walls of different hosts [grape]
The cell wall is among the first plant structures encountered by necrotrophic fungal pathogens, such as Botrytis cinerea. The composition of plant cell walls varies depending on the species, type of cell or tissue, and stage of development. Cell walls are important reservoirs of energy-rich sugars f...
ORGANISM(S): Vitis vinifera 
2014-09-24 | E-GEOD-57587 | biostudies-arrayexpress
TranscriptomicsExpanded MLST genotyping and comparative genomic hybridization of Campylobacter coli isolates from multiple hosts
Although the majority of previous work on campylobacteriosis has centered on the species Campylobacter jejuni, Campylobacter coli, the sister group to C. jejuni, is also a significant problem, but remains a much less studied organism. The purpose of this study was to develop and apply an expanded 16...
ORGANISM(S): Campylobacter coli 
2010-02-01 | E-GEOD-16787 | biostudies-arrayexpress
TranscriptomicsArabidopsis defense against Botrytis cinerea: chronology and regulation deciphered by high-resolution temporal transcriptomic analysis (time series)
A novel experimental design strategy (A Mead et al, in preparation), based on the principle of the M-bM-^@M-^\loop designM-bM-^@M-^], was developed to enable efficient extraction of information about key sample comparisons using a two-colour hybridisation experimental system. With 192 distinct sampl...
ORGANISM(S): Arabidopsis thaliana 
2012-10-02 | E-GEOD-29642 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis in Npc1-/- mouse cerebellum
Niemann-Pick Type C disease is an autosomal recessive neurodegenerative disorder with abnormal lipid storage as the major cellular pathologic hallmark. Genetic analyses have identified mutations in NPC1 gene in the great majority of cases, while mutations in NPC2 account for the remainders. Yet, lit...
ORGANISM(S): Mus musculus 
2010-08-30 | E-GEOD-20450 | biostudies-arrayexpress
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