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TranscriptomicsComparative analysis of regulatory elements between Escherichia coli and Klebsiella pneumoniae by genome-wide transcription start site profiling [TSS-Seq]
We report the application of single-molecule-based sequencing technology for high-throughput profiling of transcription start sites for two enterobacteria: Escherichia coli and Klebsiella pneumoniae.By obtaining over fourteen billion bases of sequence from 5' RACE (rapid amplification of cDNA ends) ...
ORGANISM(S): Escherichia coli K-12 
2012-07-30 | E-GEOD-35821 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of spontaneous metastasis in a K-ras/p53 mutant mouse model
The biologic basis for NSCLC metastasis is not well understood. Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified 2,209 gene...
ORGANISM(S): Mus musculus 
2009-04-14 | E-GEOD-14449 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human airway epithelium, large airways, phenotypically normal smokers vs non-smokers, MAS5 (HuGeneFL)
Upregulation of Expression of the Ubiquitin Carboxyl Terminal Hydrolase L1 Gene in Human Airway Epithelium of Cigarette Smokers; The microarray data deposited here is from 44 HuGeneFL GeneChips, from 9 normal non-smokers and 13 phenotypic normal smokers, large airways, 2 samples per individual, one ...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-5056 | biostudies-arrayexpress
UnknownCD40 induces selective routing of Ras isoforms to subcellular compartments.
Not available
S-EPMC10409697 | biostudies-literature
TranscriptomicsDefective K-Ras Oncoproteins Initiate Cancer In Vivo and Evolve to Overcome Impaired Effector Binding
The oncogenic proteins expressed in human cancer cells are exceedingly difficult targets for drug discovery due to intrinsic properties of the Ras GTPase switch. As a result, recent efforts have largely focused on inhibiting Ras-regulated kinase effector cascades, particularly the Raf/MEK/ERK and PI...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-28687 | biostudies-arrayexpress
TranscriptomicsDown-regulation of Interferon signature in systemic lupus erythematosus patients by active immunization with Interferon alpha-Kinoid
We performed a phase I/II, randomized, double-blind, placebo-controlled dose-escalation study to examine the safety, immunogenicity, and biological effects of active immunization with interferon alpha-Kinoid (IFN-K) in systemic lupus erythematosus (SLE) patients. Women 18-50 years of age with mild t...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-39088 | biostudies-arrayexpress
TranscriptomicsHeLa cell response to overexpression of wild type and mutated forms of the P19 splice variant of c-H-ras
The c-H-ras proto-oncogene undergoes alternative splicing of the exon termed IDX giving rise to a novel protein of the Ras family, p19 (H-RasIDX). The experiment tests the effect on the transcriptome of overexpressing the wild type and W164A mutated forms of p19. Keywords: genetic modification Thre...
ORGANISM(S): Homo sapiens 
2009-12-29 | E-GEOD-12059 | biostudies-arrayexpress
TranscriptomicsTranscriptomic differences between E. coli B REL606 and K-12 MG1655
Transcriptome profiles were analyzed using the samples taken at the exponential and stationary phases during the cultivation of REL606 and MG1655 in LB medium. At the exponential growth phase, most highly expressed genes of B were those for replication, translation, or nucleotide transport and metab...
ORGANISM(S): Escherichia coli 
2010-05-22 | E-GEOD-13011 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling is Superior to Procalcitonin to Discriminate Bacterial vs. Viral Lower Respiratory Tract Infections in Hospitalized Adults
Background: Distinguishing between bacterial and viral lower respiratory tract infections (LRTI) in hospitalized patients remains challenging. Transcriptional profiling is a promising tool for improving diagnosis in LRTI. Methods: We performed whole blood transcriptional analysis in a cohort of ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-60244 | biostudies-arrayexpress
TranscriptomicsDisparate Oxidant-related Gene Expression of Human Small Airway Epithelium Compared to Autologous Alveolar Macrophages
Disparate Oxidant-related Gene Expression of Human Small Airway Epithelium Compared to Autologous Alveolar Macrophages in Response to the In Vivo Oxidant Stress of Cigarette Smoking The oxidant burden of cigarette smoking induces lung cell dysfunction, and play a significant role in the pathogenesis...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-13931 | biostudies-arrayexpress
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