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TranscriptomicsInvestigation of the gene expression profile of LYVE-1-positive macrophages
LYVE-1-positive macrophages were observed to be closely spatially associated with the developing lymphatic vasculature. The role of this population of macrophages in the embryo is uncharacterised. We used microarray analyses to investigate which genes are differentially regulated between LYVE-1-posi...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-24492 | biostudies-arrayexpress
TranscriptomicsIdentification of the receptor tyrosine kinase AXL in triple negative breast cancer as a novel target for the human miR-34a microRNA (miRNA study)
Triple negative breast cancer (TNBC) is histologically characterized by the absence of the hormone receptors estrogen and progesterone, in addition to having a negative immunostain for HER-2. The aggressiveness of this disease and lack of targeted therapeutic options for treatment is of high clinic...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21719 | biostudies-arrayexpress
GenomicsChIP-Seq on SOX7-V5 tagged mouse embryos at E9.5 and E10.5
We intended to identify the potential binding targets of SOX7 in mouse during development (E9.5-E10.5)
ORGANISM(S): Mus musculus 
2022-12-30 | E-MTAB-12320 | biostudies-arrayexpress
TranscriptomicsThe E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity
Analysis of gene expression altered upon knockdown of Siah2 in prosate cancer cells. The objective is to elucidate which signaling pathways or transcription factors are regulated by the E3 ubiquitin ligase Siah2 in human prostate cancer cells. CWR22Rv1 cells were in fected with pLKO.1 control or Sia...
ORGANISM(S): Homo sapiens 
2013-03-19 | E-GEOD-38851 | biostudies-arrayexpress
TranscriptomicsAXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.
Phosphoinositide-3-kinase (PI3K)-α inhibitors are clinically active in squamous carcinoma (SCC) of the head and neck (H&N) bearing mutations or amplification of PIK3CA. We aimed to identify potential mechanism of resistance and have observed that SCCs cells overcome the antitumor effects of the PI3K...
ORGANISM(S): Homo sapiens 
2015-04-12 | E-GEOD-61515 | biostudies-arrayexpress
TranscriptomicsGenome-wide studies of histone Me2 SWIRM and polyamine oxidase domain homologues of mammalian LSD1
In order to gain a more global view of the activity of histone demethylases we report here studies of the two fission yeast SWIRM and polyamine oxidase domain homologues of mammalian LSD1. Consistent with previous work (Nicolas et al., 2006) we find that the two S. pombe proteins, which we name Swm...
ORGANISM(S): Schizosaccharomyces pombe 
2010-05-27 | E-GEOD-6224 | biostudies-arrayexpress
TranscriptomicsAlternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct
Macrophages adopt an alternatively activated phenotype (AAM) when activated by IL-4. While these AAMs can be derived from local proliferation of resident tissue macrophages or recruited inflammatory monocytes, it is not known whether these different AAMs are phenotypically and functionally distinct....
ORGANISM(S): Mus musculus 
2014-02-05 | E-GEOD-54679 | biostudies-arrayexpress
TranscriptomicsPharmacodynamic effects of GLP-1 agonist liraglutide in adolescent, prediabetic pigs
GLP-1 agonists are potent glucose-lowering agents, however, their effect on adolescent organisms needs to be clarified Transgenic pigs expressing a dominant-negative GLP receptor randomly assigned for a 90 day treatment trial with liraglutide (0.6-1.8 mg per day)/placebo
ORGANISM(S): Sus scrofa 
2015-12-31 | E-GEOD-56427 | biostudies-arrayexpress
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