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TranscriptomicsSpecific inhibition of p300-HAT alters Global Gene Expression and Repress HIV replication
Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, neurodegenaration, asthma, diabetes, AIDS and cardiac hypertrophy. We describe the synthesis and characte...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-7818 | biostudies-arrayexpress
TranscriptomicsExpression profiles of the NuB4/HAT-B complex and histone knockouts
Dynamic modification of histone proteins plays a key role in regulating gene expression. However, histones themselves can also be dynamic, which potentially affects the stability of histone modifications. To determine the molecular mechanisms of histone turnover we developed a parallel screening met...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-14 | E-GEOD-30168 | biostudies-arrayexpress
TranscriptomicsHat mutants
Transcriptomes from the hat1, hat2 and hat1 hat2 mutants in S288C yeast background.
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-09 | E-GEOD-2434 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis overexpressing At3g42170 hAT-like transposase
The effect of overexpression of the At3g42170 hAT-like transposase on plant gene expression
ORGANISM(S): Arabidopsis thaliana 
2005-03-10 | E-MEXP-279 | biostudies-arrayexpress
GenomicsCampylobacter jejuni strain:CNH-HAT-1 | isolate:not applicable
Campylobacter jejuni strain:CNH-HAT-1 | isolate:not applicable Genome sequencing
PRJNA1170262 | ENA
TranscriptomicsHistone acetylation dependent microarray analysis uncovers a role for Tip60 HAT activity in nervous system function and general metabolism
Tip60 is a key histone acetyltransferase (HAT) enzyme that plays a central role in diverse biological processes critical for general cell function, however the chromatin-mediated cell-type specific developmental pathways that are dependent exclusively upon the HAT activity of Tip60 remain to be expl...
ORGANISM(S): Drosophila melanogaster 
2010-11-29 | E-GEOD-25635 | biostudies-arrayexpress
ProteomicsNuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity
The transcriptional co-activator and acetyltransferase p300 is required for fundamental cellular processes, including differentiation and growth. Here, we report that p300 forms phase separated condensates in the cell nucleus. The phase separation ability of p300 is regulated by autoacetylation and ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-26 | PXD026898 | Pride
P300 nuclear condensates hat activity 
TranscriptomicsTip60 HAT action mediates environmental enrichment induced cognitive restoration
Environmental enrichment (EE) conditions have profound beneficial effects for reinstating cognitive ability in neuropathological disorders like Alzheimer’s disease (AD). While EE benefits involve epigenetic gene control mechanisms that comprise histone acetylation, the histone acetyltransferases...
ORGANISM(S): Drosophila melanogaster 
2016-01-07 | E-GEOD-76612 | biostudies-arrayexpress
TranscriptomicsJade1 ChIP-chip on ENCODE Tiling array
Several MYST-family histone acetyltransferase (HAT) enzymes associate with specific ING tumor suppressor proteins. ING complexes containing the HBO1 HAT protein are the major source of histone H4 acetylation in vivo and have been shown to play critical roles in gene regulation and DNA replication. H...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-14309 | biostudies-arrayexpress
TranscriptomicsExpression profile of melanoma cells following p300 HAT inhibition
Epigenetic events, including covalent post-translational modification of histones, have frequently been demonstrated to play critical roles in tumor development and progression. The transcriptional coactivator, p300/CBP, possesses both histone acetyltransferase (HAT) activity as well as scaffolding ...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-45981 | biostudies-arrayexpress
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