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TranscriptomicsIdentification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study
The aim of this study was to identify the specific molecular biological features predicting the therapeutic outcomes of three bDMARDs, infliximab (IFX), tocilizumab (TCZ), and abatacept (ABT) by studying blood gene expression signature of patients prior to biologic treatment in a unified test platfo...
ORGANISM(S): Homo sapiens 
2016-07-21 | E-GEOD-78068 | biostudies-arrayexpress
TranscriptomicsCardiac phase-targeted dynamic load on left ventricle differentially regulates phase-sensitive gene expressions and pathway activation
Each heart was assigned to one of the following three conditions: phasic systolic overload (SO), phasic diastolic overload (DO), and no loading throughout the cardiac cycle (control; CN). We created SO by isovolumic contraction (peak systolic LVP > 170 mmHg) at a constant diastolic volume with end-d...
ORGANISM(S): Rattus norvegicus 
2013-02-07 | E-GEOD-44108 | biostudies-arrayexpress
TranscriptomicsDer f/SEB-induced skin inflammation
Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease. We recently described an animal model in which repeated epicutaneous applications of a house dust mite extract and Staphylococcal enterotoxin B induced eczematous skin lesions. In this study we showed that global gene expression...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-53132 | biostudies-arrayexpress
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