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TranscriptomicsTranscription profiling of normal v early MDS v non-MDS anemia bone marrow CD34 cells to identify biomarkers of disease
Early, low risk IPSS (International Prognostic Scoring System) myelodysplasia (MDS) is a heterogeneous disorder where the molecular and cellular haematopoietic defects are poorly understood. To gain insight into this condition, we analyzed gene expression profiles of marrow CD34+ progenitor cells fr...
ORGANISM(S): Homo sapiens 
2007-09-20 | E-GEOD-2779 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression in Sézary syndrome: Identification, function and diagnostic potential.
MicroRNAs are commonly aberrantly expressed in many cancers. Very little is known of their role in T-cell lymphoma, however. We therefore elucidated the complete miRNome of purified T-cells cells from 21 patients diagnosed with Sézary syndrome (SzS), a rare aggressive primary cutaneous T-cell (CD4+)...
ORGANISM(S): Homo sapiens 
2010-05-12 | E-GEOD-21697 | biostudies-arrayexpress
TranscriptomicsHedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model
The Sonic Hedgehog (Shh) pathway drives a subset of medulloblastomas, a malignant neuroectodermal brain cancer, and other cancers. Small-molecule Shh pathway inhibitors have induced tumor regression in mice and patients with medulloblastoma; however, drug resistance rapidly emerges, in some cases vi...
ORGANISM(S): Mus musculus 
2012-04-19 | E-GEOD-37417 | biostudies-arrayexpress
TranscriptomicsMicroRNA Expression in Multiple Myeloma is Associated with Genetic Subtype, Isotype and Prognostic Outcome
MicroRNAs are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many cancers including lymphoma. However, the role of microRNAs in the pathogenesis of multiple myeloma (MM) is poorly understood. We therefore elucidated the complete miRNome of puri...
ORGANISM(S): Homo sapiens 
2010-09-29 | E-GEOD-24371 | biostudies-arrayexpress
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