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TranscriptomicsGene expression profiles of Sunitinib-treated but not untreated short-term serum-free cultures predict treatment response of human high-grade gliomas in vitro
High-grade gliomas are amongst the most deadly human tumors. Treatment results are overall disappointing. Nevertheless, in several trials around 20% of patients respond to therapy. Diagnostic strategies to identify those patients that will ultimately profit from a specific targeted therapy are urgen...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-51305 | biostudies-arrayexpress
UnknownDeath induced by CD95 or CD95 ligand elimination.
Not available
S-EPMC4083055 | biostudies-literature
TranscriptomicsPlasmodium knowlesi gene expression differs in ex vivo compared to in vitro blood-stage cultures
The purpose of this reasearch is to identify and evaluate the global gene expression of Plasmodium knowlesi blood-stage parasites and specifically compare the gene expression profiles of samples derived from ex vivo versus long-term in vitro cultures. For ex vivo samples, a rhesus monkey was infecte...
ORGANISM(S): Plasmodium knowlesi 
2015-06-08 | E-GEOD-62886 | biostudies-arrayexpress
UnknownPlatinum and etoposide chemotherapy, durvalumab with thoracic radiotherapy in the first-line treatment of patients with extensive-stage small-cell lung cancer: CHEST-RT (TROG 20.01) Trial - protocol for a phase II study.
Not available
S-EPMC12258326 | biostudies-literature
UnknownCD95 and CD95L promote and protect cancer stem cells.
Not available
S-EPMC4417339 | biostudies-literature
TranscriptomicsTranscription profiling of human glioma cell lines reveals CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and expression profiles
We cultured tumor cells from 22 GBM under medium conditions favoring the growth of neural stem cells. 11 out of 15 primary GBM contained a significant CD133+ subpopulation that comprised cells showing all hallmarks of neural stem cells. Cell lines derived from these CD133+ GBM showed a neurosphere-l...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-7181 | biostudies-arrayexpress
TranscriptomicsValidation study: Response-predictive gene expression profiling of glioma progenitor cells in vitro
Background. In a previous publication we introduced a novel approach to identify genes that hold predictive information about treatment outcome. A linear regression model was fitted by using the least angle regression algorithm (LARS) with the expression profiles of a construction set of 18 glioma p...
ORGANISM(S): Homo sapiens 
2016-02-21 | E-GEOD-76990 | biostudies-arrayexpress
UnknownFirst-line chemoimmunotherapy and immunotherapy in patients with non-small cell lung cancer and brain metastases: a registry study.
Not available
S-EPMC10885799 | biostudies-literature
TranscriptomicsGene array data for Fas knock-out human cancer cell line and mouse liver tissue
CD95 (also called FAS and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through induction of apoptosis. During cancer progression CD95 is frequently downregulated or cells are rendered apoptosis resistant raising the possibility that loss of CD...
ORGANISM(S): Homo sapiens 
2010-04-02 | E-GEOD-21154 | biostudies-arrayexpress
UnknownHigher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC11872607 | biostudies-literature
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