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UnknownIn Situ Grignard Metalation Method for the Synthesis of Hauser Bases.
The in situ Grignard Metalation Method (iGMM) is a straightforward one-pot procedure to quickly produce multigram amounts of Hauser bases R2 N-MgBr which are valuable and vastly used metalation reagents and novel electrolytes for magnesium batteries. During addition of bromoethane to a su...
S-EPMC9546396 | biostudies-literature
UnknownExome and copy number variation analyses of Mayer-Rokitansky-Kuster- Hauser syndrome.
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital absence of the vagina and uterus. We conducted genome-wide SNP analyses and exome sequencing to detect the causes of MRKH syndrome. We identified de novo variants of MYCBP2, NAV3, and PTPN3 in three fa...
S-EPMC6160444 | biostudies-literature
UnknownA New Ten-Step Surgical Approach to Mayer-Rokitansky-Kuster-Hauser Syndrome-A Preliminary Report of Three Cases.
Background: Vaginal reconstruction procedures for patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) have the main purpose of restoring the anatomy to increase the quality of life of these patients. To describe the surgical treatment of patients with type I Mayer-Rokitansky-Küster-H...
S-EPMC11856762 | biostudies-literature
UnknownMolecular identification of a calcium-inhibited catalytic subunit of casein kinase type 2 from Paramecium tetraurelia.
We have previously described the occurrence in Paramecium of a casein kinase (CK) activity (EC 2.7.1.37) with some unusual properties, including inhibition by Ca(2+) (R. Kissmehl, T. Treptau, K. Hauser, and H. Plattner, FEBS Lett. 402:227-235, 1995). We now have cloned four genes, PtCK2alpha1 to PtC...
S-EPMC326640 | biostudies-literature
UnknownSystematic Enzyme Mapping of Cellular Metabolism by Phasor-Analyzed Label-Free NAD(P)H Fluorescence Lifetime Imaging.
In the past years, cellular metabolism of the immune system experienced a revival, as it has become clear that it is not merely responsible for the cellular energy supply, but also impacts on many signaling pathways and, thus, on diverse cellular functions. Label-free fluorescence lifetime imaging o...
S-EPMC6887798 | biostudies-literature
UnknownRecent advances in the molecular mechanisms of Mayer-Rokitansky-Kuster-Hauser syndrome.
Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is a disease caused by congenital absence of the uterus and two-thirds of the upper vagina. The pathogenic mechanism of MRKHS may involve gene abnormalities, and there are various case reports associating MRKHS with the Wnt family member 4 (Wnt4...
S-EPMC5526143 | biostudies-literature
UnknownAssembly and annotation of Pneumocystis jirovecii from the human lung microbiome.
Pneumocystis jirovecii is a fungus that causes Pneumocystis pneumonia in immunosuppressed patients and has been closely associated with AIDS since the beginning of the AIDS epidemic. Because in vitro cultivation of P. jirovecii is not possible, progress has been hindered in our understanding of its ...
S-EPMC3634608 | biostudies-literature
UnknownAn Association between EMX2 Variations and Mayer-Rokitansky-Kuster-Hauser Syndrome: A Case-Control Study of Chinese Women.
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital malformations of Müllerian structures, including the uterus and upper two-thirds of the vagina in women. Until now, the etiology of this disease has remained unknown. We hypothesized that EMX2 (the human homologue of Dr...
S-EPMC9020933 | biostudies-literature
UnknownNAD(P)H Oxidase Activity in the Small Intestine Is Predominantly Found in Enterocytes, Not Professional Phagocytes.
The balance between various cellular subsets of the innate and adaptive immune system and microbiota in the gastrointestinal tract is carefully regulated to maintain tolerance to the normal flora and dietary antigens, while protecting against pathogens. The intestinal epithelial cells and the networ...
S-EPMC5983677 | biostudies-literature
UnknownReshaping the Bet v 1 fold modulates T(H) polarization.

Background

Several alternative mechanisms have been proposed to explain why some proteins are able to induce a T(H)2-biased and IgE-mediated immune response. These include specific interactions with receptors of the innate immune system, proteolytic activities, allergen-associated carbohydra...
S-EPMC5689381 | biostudies-literature
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