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MetabolomicsMetabolomic Characterization of Knock-Out Mutants in Arabidopsis - Development of a Metabolite Profiling Database for Knock-Out Mutants in Arabidopsis (MeKO)
Despite recent intensive research efforts in functional genomics, the functions of only a limited number of Arabidopsis (Arabidopsis thaliana) genes have been determined experimentally. Thus, improving gene annotation remains a major challenge in plant science. Because metabolite profiling can chara...
2014-03-01 | MTBLS47 | MetaboLights
TranscriptomicsAlteration of gene expression in human T cells treated with JPH203
To indentify the effect of JPH203 on the gene expression in activated T cells, microarray analysis was performed using activated human T cells derived from peripheral blood. Human CD4+ T cells from peripheral blood in healthy volunteer were activated with anti-CD3 and anti-CD28 in the presence of ...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-48578 | biostudies-arrayexpress
MetabolomicsMetabolomic correlation-network modules in Arabidopsis based on a graph-clustering approach
Deciphering the metabolome is essential for a better understanding of the cellular metabolism as a system. Typical metabolomics data show a few but significant correlations among metabolite levels when data sampling is repeated across individuals grown under strictly controlled conditions. Although ...
2014-03-01 | MTBLS45 | MetaboLights
TranscriptomicsTCR repertoire analysis by Next-generation sequencing of mouse CD8+ T cells in spleen or tumor
We have reported that intra-tumoral treatment with 1V270, a phospholipid-conjugated TLR7 agonist,induces local expansion an systemic dispersion of oligoclonal tumor-specific T cells by TCR repertoire analysis using next generation RNAseq methodology. Here, we examined whether systemic 1V270 therapy ...
ORGANISM(S): Mus musculus 
2018-07-31 | E-MTAB-6566 | biostudies-arrayexpress
UnknownInterruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery.
Not available
S-EPMC10992266 | biostudies-literature
UnknownA clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy.
Not available
S-EPMC7814014 | biostudies-literature
GenomicsA mesodermal factor, T (Brachyury), specifies mouse germ cell fate by directly activating germline determinants
Germ cells ensure reproduction and heredity in metazoans. Primordial germ cells (PGCs) in mice are induced in pluripotent epiblasts by BMP4 and WNT3, yet their mechanism of action remains unclear. Here, using in vitro PGC specification system, we show that WNT3 induces many transcription factors a...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-50394 | biostudies-arrayexpress
UnknownReduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes.
Not available
S-EPMC10310836 | biostudies-literature
TranscriptomicsInduction of the mouse germ cell fate by transcription factors in vitro [exp1]
The germ cell lineage ensures the continuity of life through the generation of male and female gametes, which unite to form a totipotent zygote. We have established a culture system that recapitulates the mouse germ-cell specification pathway: Using cytokines, embryonic stem cells (ESCs)/induced plu...
ORGANISM(S): Mus musculus 
2013-08-04 | E-GEOD-43775 | biostudies-arrayexpress
UnknownGenetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan.
Not available
S-EPMC5550785 | biostudies-literature
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