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TranscriptomicsGenome-wide localization of ORC and MCM binding sites and identification of replication origins in S. pombe
DNA replication of eukaryotic chromosomes initiates at a number of discrete loci, called replication origins. Distribution and regulation of origins are important for complete duplication of the genome. Here, we determined locations of Orc1 and Mcm6, components of pre-replicative complex (pre-RC),...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-11 | E-GEOD-6523 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
UnknownHMGA2 promotes platelet-neutrophil complex formation and pulmonary tissue damage in myelodysplastic syndromes.
Not available
S-EPMC12320400 | biostudies-literature
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
UnknownUnraveling the impact of crizotinib to promote megakaryopoiesis for alleviating thrombocytopenia in myelodysplastic neoplasms.
Not available
S-EPMC12589124 | biostudies-literature
UnknownIL36G-producing neutrophil-like monocytes promote cachexia in cancer.
Not available
S-EPMC11393454 | biostudies-literature
ProteomicsInteractome analysis for Gore-tex/Osiris23 and identification of ubiquitination sites in Gore-tex/Osiris23
To identify the proteins interacting with Gore-tex/Osiris23, affinity purification mass spectrometry (AP-MS) was performed using S2 cells transfected with HA or Flag-tagged Gore-tex/Osiris23 expression vectors. PTM analysis was also performed to determine the ubiquitination sites of Gore-tex/Osiris2...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2026-03-12 | PXD053779 | JPOST Repository
UnknownHigh-Dose Intravenous Ferric Carboxymaltose/Derisomaltose Without ESAs for Cancer-Related Anemia in Japan: A Retrospective Single-Center Cohort Study.
Not available
S-EPMC12896494 | biostudies-literature
UnknownDeciphering state-dependent immune features from multi-layer omics data at single-cell resolution.
Not available
S-EPMC12339405 | biostudies-literature
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