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TranscriptomicsGlucosylated hydroxymethyluracil (DNA base J) prevents transcriptional read-through in Leishmania
Some T's in nuclear DNA of trypanosomes and Leishmania are hydroxylated and glucosylated to yield base J (?-D-glucosyl-hydroxymethyluracil). In Leishmania about 99% of J is located in telomeric repeats. We show here that most of the remaining J is located at chromosome-internal RNA Polymerase II ter...
ORGANISM(S): Leishmania major 
2011-10-15 | E-GEOD-32976 | biostudies-arrayexpress
UnknownCommunity pharmacy: a crucial enabler in creating the effectiveness study environment in the Salford Lung Studies.
Not available
S-EPMC7586830 | biostudies-literature
UnknownA method for overcoming plasma protein inhibition of tyrosine kinase inhibitors.
Not available
S-EPMC8478262 | biostudies-literature
MetabolomicsSimultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics
Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provides an opportunity to simultaneously gain deep insights int...
2023-07-03 | MTBLS2746 | MetaboLights
UnknownLifetime reproductive benefits of cooperative polygamy vary for males and females in the acorn woodpecker (Melanerpes formicivorus).
Not available
S-EPMC8370801 | biostudies-literature
UnknownLifetime inclusive fitness effects of cooperative polygamy in the acorn woodpecker.
Not available
S-EPMC10175847 | biostudies-literature
UnknownPreconceptual administration of doxycycline in women with recurrent miscarriage and chronic endometritis: protocol for the Chronic Endometritis and Recurrent Miscarriage (CERM) trial, a multicentre, double-blind, placebo-controlled, adaptive randomised trial with an embedded translational substudy.
Not available
S-EPMC10693855 | biostudies-literature
TranscriptomicsIron uptake controls the generation of Leishmania infective forms through regulation of ROS levels .
During its life cycle Leishmania undergoes extreme environmental changes, alternating between insect vectors and vertebrate hosts. In mammals the parasites replicate within parasitophorous vacuoles of macrophages, compartments that contain low concentrations of iron. Here we show that stimulation of...
ORGANISM(S): Leishmania amazonensis 
2012-12-15 | E-GEOD-41641 | biostudies-arrayexpress
UnknownEstimated activity levels in dogs at population scale with linear and causal modeling.
Not available
S-EPMC12287635 | biostudies-literature
UnknownNeuropsychiatric research databases for people with intellectual disabilities and epilepsy (REFINE): a feasibility study protocol.
Not available
S-EPMC12658526 | biostudies-literature
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