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TranscriptomicsGene expression data following heptose-bisphosphate (HBP) treatment of Jurkat T cells
Host recognition of pathogen-associated molecular patterns (PAMPs) initiates an innate immune response that is critical for pathogen elimination and engagement of adaptive immunity. Here we show that mammalian cells can detect and respond to the bacterial-derived monosaccharide heptose-1,7-bisphosph...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-67840 | biostudies-arrayexpress
UnknownGFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway.
Not available
S-EPMC8661546 | biostudies-literature
TranscriptomicsGene expression data following heptose-bisphosphate (HBP) treatment of Jurkat T cells
Host recognition of pathogen-associated molecular patterns (PAMPs) initiates an innate immune response that is critical for pathogen elimination and engagement of adaptive immunity. Here we show that mammalian cells can detect and respond to the bacterial-derived monosaccharide heptose-1,7-bisphosph...
ORGANISM(S): Homo sapiens 
2015-04-15 | GSE67840 | GEO
TranscriptomicsGlycosylation regulates the stability of c-MYC
Tumorigenesis is characterised by changes in transcriptional regulation and the androgen receptor (AR) has been identified as a key driver in prostate cancer. In this study, we show that the hexosamine biosynthetic pathway (HBP) genes are overexpressed in clinical prostate cancer and androgen-regula...
ORGANISM(S): Homo sapiens 
2013-05-30 | E-GEOD-44624 | biostudies-arrayexpress
UnknownThe HBP Pathway Inhibitor FR054 Enhances Temozolomide Sensitivity in Glioblastoma Cells by Promoting Ferroptosis and Inhibiting O-GlcNAcylation.
Not available
S-EPMC12329428 | biostudies-literature
GenomicsHomo sapiens
Gene expression data following heptose-bisphosphate (HBP) treatment of Jurkat T cells
PRJNA281055 | ENA
TranscriptomicsPathway-based integrative analysis reveals a key role for the hexosamine biosynthetic pathway in castrate resistant prostate cancer with therapeutic implications
The development and progression of castrate resistant prostate cancer (CRPC), a lethal disease, is thought to be driven by multiple events. A hallmark of CRPC is the ability to evade the cytotoxic effects of anti-androgen therapy. Importantly, persistent androgen receptor (AR) signalling is thought ...
ORGANISM(S): Homo sapiens 
2015-04-03 | E-GEOD-67537 | biostudies-arrayexpress
UnknownSuppression of the HBP Function Increases Pancreatic Cancer Cell Sensitivity to a Pan-RAS Inhibitor.
Not available
S-EPMC7923121 | biostudies-literature
TranscriptomicsPathway based integrative analysis reveals a key role for the hexosamine biosynthetic pathway in prostate cancer progression with therapeutic implications
To better understand the biochemical changes associated with castrate resistant prostate cancer (CRPC), we developed a pathway-based integrated analytical method to examine prostate cancer (PCa) gene expression and metabolomic datasets and found distinct alterations in the Hexosamine Biosynthetic Pa...
ORGANISM(S): Homo sapiens 
2016-09-20 | GSE50661 | GEO
UnknownInsights into Mobile Genetic Elements of the Biocide-Degrading Bacterium Pseudomonas nitroreducens HBP-1.
Not available
S-EPMC7466150 | biostudies-literature
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