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MetabolomicsUntargeted metabolomic profiling of HCT116 cells following DHODH and JNK inhibition

Untargeted LC-MS metabolomics was used to investigate metabolic alterations associated with DHODH inhibition and JNK signaling in colorectal cancer. The study included control, DHODH inhibitor treated, JNK inhibitor treated, and combined treatment groups, with pooled quality control samples for a...

2026-08-13 | MTBLS15162 | MetaboLights
TranscriptomicsMicroarray analysis of HCT‑116 cells during in vitro culture over time
Human cancer cell lines are frequently used in controlled culture systems to investigate cancer biology. However, extended cultivation can introduce genomic and transcriptional instability. The cell line HCT-116 is a well characterized and widely used model for colorectal cancer. To assess transcrip...
ORGANISM(S): Homo sapiens 
2026-04-07 | E-MTAB-16637 | biostudies-arrayexpress
MetabolomicsFASN effect on HCT116 metabolism probed by 13C6-glucose tracer (part II)
Not available
ORGANISM(S): Homo sapiens 
ST001046 | MetabolomicsWorkbench
MetabolomicsFASN effect on HCT116 metabolism probed by 13C6-glucose tracer (part I)
Not available
ORGANISM(S): Homo sapiens 
ST001045 | MetabolomicsWorkbench
TranscriptomicsExpression data from Che-1 (AATF) depleted HCT 116 cell line
Che-1 is a RNA Polymerase II binding protein involved in the regulation of gene transcription. Che-1 emerges as an important adaptor that connects transcriptional regulation, cell-cycle progression, checkpoint control, and apoptosis. We have observed that Che-1 depletion sensitizes cells to chemothe...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-GEOD-45009 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the human colorectal adenocarcinoma cell line HCT-116 treated with 5-aza-2’-deoxycytidine
We performed poly(A)+ stranded RNA-seq of a panel of the human colorectal adenocarcinoma cell line HCT-116 treated with 5-aza-2’-deoxycytidine. In parallel, we determined the genomic location and DNA methylation levels of human full-length LINE-1 elements (L1) from the same samples using bs-ATLAS-se...
ORGANISM(S): Homo sapiens 
2023-09-21 | E-MTAB-12245 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of HCT-116 versus HCT-116 treated with 5-aza-2'-deoxycytidine processing human colon cancer cell lines
UCRs expression signature of HCT-116 cell lines versus HCT-116 cell line treated with DNA methylation inhibitor 5-aza-2'-deoxycytidine
ORGANISM(S): Homo sapiens 
2010-03-09 | E-MTAB-196 | biostudies-arrayexpress
MetabolomicsCurcumin (analogue) metabolites in intestinal cell lines
Curcumin and curcumin-based benzothiazepane analogues were investigated in intestinal cell lines of cancer (HCT-116) and non-cancer (IPEC-J2) origin. After 0h, 3h and 15h incubation, the cell lysates and extracellular media were analysed using LC-QTOF-MS.
2026-07-20 | MTBLS15099 | MetaboLights
TranscriptomicsRNAi knock down of mSin3a-b and SBTB4 in human colon carcinoma cell line HCT116
Efffects of silencing ZBTB4, mSin3a/mSin3b on HCT 116 human colon carcinoma cell lines for 48 hours
ORGANISM(S): Homo sapiens 
2008-03-31 | E-MEXP-1509 | biostudies-arrayexpress
GenomicsHomo sapiens strain:HCT-116,HT-29 | breed:cell
Homo sapiens strain:HCT-116,HT-29 | breed:cell Transcriptome or Gene expression
PRJNA933002 | ENA
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