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Metabolomicsβ-Hydroxybutyrate Restores Social Deficits via Suppressing HDAC9 in the Anterior Cingulate Cortex of Shank3B-Deficient Mice

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
GenomicsHistone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (ChIP-Seq)
We report the genomic regions enriched in Histone Deacetylase 3 (HDAC3) in mouse bone marrow derived macrophages. Furthermore, we also report the genomic acetylation pattern on Histone 3, Lysine 9 (H3K9) in macrophages with and without HDAC3 and/or treated with Th2 cytokine IL-4. HDAC3 enriched gen...
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-33596 | biostudies-arrayexpress
GenomicsDiurnal changes of HDAC3, Rev-erbα, NCoR and Pol II recruitment to the mouse liver genome and of H3K9Ac
We reported a diurnal changes in the recruitment of HDAC3, Rev-erbα, NCoR and Pol II to the mouse liver genome as well as H3K9 acetylation in vivo at ZT10 and ZT22. ChIP-Seq profiling of HDAC3, Rev-erbα, NCoR and Pol II binding and H3K9Ac in mouse liver harvested at 2 different times (ZT10 and ZT22)...
ORGANISM(S): Mus musculus 
2011-03-11 | E-GEOD-26345 | biostudies-arrayexpress
GenomicsHDAC3-dependent regulation of H3K9 acetylation in IECs
The development and severity of inflammatory bowel diseases (IBD) and other chronic inflammatory conditions can be influenced by host genetic and environmental factors, including signals derived from commensal bacteria. However, the mechanisms that integrate these diverse cues remain undefined. Her...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-50453 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse heart deficient of HDAC3
Gene expression changes in the heart of MCH3-KO mouse (HDAC3 f/f, Muscle Creatine Kinase-Cre) versus control WT mouse (HDAC3 f/f). Histone deacetylases (HDACs) play important roles in cardiac development and function. We show here that mice deficient of HDAC3 in heart and skeletabl muscle are relati...
ORGANISM(S): Mus musculus 
2011-09-20 | E-GEOD-31251 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse liver depleted of HDAC3
Liver-specific depletion of HDAC3 leads to liver steatosis (fatty liver), suggesting disregulation of lipid metabolism. This is correlated with changes in lipid metabolic gene expression. Livers depleted of HDAC3 were removed from 12 week old male HDAC3 fl/fl mice (loxP sites flanking exon 4 to 7 of...
ORGANISM(S): Mus musculus 
2011-03-11 | E-GEOD-25937 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq comparing WT, HDAC3 and Dax1 knock-out clones in SL(RA) differentiation conditions
We performed single-cell RNA-seq in order to characterize in high resolution the transcriptomic profiles, differentiation fates and heterogeneity of wild-type, HDAC3 or Dax1 knock-out cells in SL(RA) differentiation conditions.
ORGANISM(S): Mus musculus 
2021-03-15 | E-MTAB-10147 | biostudies-arrayexpress
TranscriptomicsRNA-seq comparing WT to HDAC3 and Dax1 knock-out clones in cell-sorted populations in 2iLIF and SL(RA) differentiation conditions
In order to determine the transcriptomic profiles of PrE-induced cells following HDAC3 or Dax1 knock-out in SL(RA) differentiation conditions, RNA-seq was performed on Gata6+ or Nanog+ sort-selected cells. Profiles are contrasted with WT cells in the same differentiation conditions as well as to mo...
ORGANISM(S): Mus musculus 
2021-03-15 | E-MTAB-10150 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expression in IECs by HDAC3
The development and severity of inflammatory bowel diseases (IBD) and other chronic inflammatory conditions can be influenced by host genetic and environmental factors, including signals derived from commensal bacteria. However, the mechanisms that integrate these diverse cues remain undefined. Her...
ORGANISM(S): Mus musculus 
2013-11-12 | E-GEOD-50188 | biostudies-arrayexpress
TranscriptomicsDetermine the effects of Hdac3 deletion on H3K27ac profiles in murine chondrocytes
Histone deacetylase inhibitors are efficacious epigenetic-based therapies for some cancers and neurological disorders; however, these drugs inhibit multiple Hdacs and have detrimental effects on the pre- and post-natal skeleton. To better understand how Hdac inhibitors affect the skeleton, we focus...
ORGANISM(S): Mus musculus 
2016-08-10 | E-GEOD-75552 | biostudies-arrayexpress
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