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TranscriptomicsCardiac transcription factors in HL-1 cells: gene expression and genome binding profiling
[1] Gene expression profiling in Gata4, Mef2a knockdown in HL-1 cells. HL-1 cells infected with adenovirus expressing either control siRNA or Gata4, and Gata4 & Mef2a siRNA. [2] Genome-wide maps of cardiac transcription factors binding region in HL-1 cells. We performed bio-ChIP-seq using streptavi...
ORGANISM(S): Mus musculus 
2011-03-02 | E-GEOD-21529 | biostudies-arrayexpress
UnknownAssessment of genetic diversity in seed plants based on a uniform π criterion.
Not available
S-EPMC6271616 | biostudies-literature
TranscriptomicsGenome-wide profiling of E12.5 cardiomyocytes RNA expression in both heterozygous control and mutant
Congenital heart disease is among the most frequent major birth defects. Epigenetic marks are crucial for organogenesis, but their role in heart development is poorly understood. Polycomb Repressive Complex 2 (PRC2) trimethylates histone H3 at lysine 27, establishing H3K27me3 repressive epigenetic m...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-29992 | biostudies-arrayexpress
GenomicsA genome-wide approach to delineate novel XBP-1 targets involved in liver metabolism
This experiment was conducted to identify novel XBP-1 targets involved in liver metabolism. The following abstract from the submitted manuscript describes the major findings of this work. The IRE1a-XBP1s axis regulates the COPII-mediated secretory program in response to nutrient availability. Lin Li...
ORGANISM(S): Mus musculus 
2019-06-03 | GSE101202 | GEO
GenomicsChIP-seq of Ezh2 and H3K27me3 in E12.5 heart apex
Ezh2 and H3K27me3 binding sites in E12.5 heart apex PRC2 binding sites in wild type cardiomyocytes
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-29994 | biostudies-arrayexpress
GenomicsReinstatement of developmental stage-specific GATA4 enhancers controls the gene expression program in heart disease
Through integration of GATA4 genome-wide occupancy and RNA-seq dataset in embryonic conditional knockout heart, we identified a class of the master cardiac regulator GATA4 bound enhancers. With combinatorial assembly of chromatin signatures, we further refined that a unique type of fetal distal GATA...
ORGANISM(S): Mus musculus 
2014-08-13 | E-GEOD-52123 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of liver transcriptomes from wild type and Ern1-LKO mice
This experiment was conducted to identify mRNA transcripts alteration in liver of Ern1 liver specific knockout mice. The following abstract from the submitted manuscript describes the major findings of this work. The IRE1a-XBP1s axis regulates the COPII-mediated secretory program in response to nutr...
ORGANISM(S): Mus musculus 
2019-06-03 | GSE100358 | GEO
TranscriptomicsmicroRNA-1 negatively regulates expression of the hypertrophy-associated genes calmodulin and Mef2a
Calcium signaling is a central regulator of cardiomyocyte growth and function. Calmodulin is a critical mediator of calcium signals. Because the amount of calmodulin within cardiomyocytes is limiting, precise regulation of calmodulin expression may be an important for regulation of calcium signaling...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-13874 | biostudies-arrayexpress
GenomicsPre-configuring chromatin architecture with histone modifications guide hematopoietic stem cell formation in mouse embryos [ChIP-seq]
Pre-configuring chromatin architecture with histone modifications guide hematopoietic stem cell formation in mouse embryos [ChIP-seq]
PRJNA677890 | ENA
GenomicsPre-configuring chromatin architecture with histone modifications guide hematopoietic stem cell formation in mouse embryos [Hi-C]
Pre-configuring chromatin architecture with histone modifications guide hematopoietic stem cell formation in mouse embryos [Hi-C]
PRJNA677891 | ENA
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