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TranscriptomicsA high-resolution single-cell multiomic atlas of the human fetal lung - scRNA / GEX / VDJ
We obtained human embryonic and fetal lungs from 5-22 pcw for scRNAseq and scATACseq analysis. To focus on epithelial differentiation and region specialization, we deeply sampled 15, 18, 20 and 22 pcw lungs and separated proximal and distal regions while leaving lungs at 5, 6, 9 and 11 pcw intact. T...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11278 | biostudies-arrayexpress
UnknownTemperate seaweeds Himanthalia elongata and Fucus vesiculosus significantly reduce rumen methane emissions in vitro due to their high phlorotannin content.
Not available
S-EPMC12439089 | biostudies-literature
MetabolomicsGeneration of a chromosome-scale genome assembly of the insect-repellent terpenoid-producing Lamiaceae species, Callicarpa americana

BACKGROUND: Plants exhibit wide chemical diversity due to the production of specialized metabolites that function as pollinator attractants, defensive compounds, and signaling molecules. Lamiaceae (mints) are known for their chemodiversity and have been cultivated for use as culi...

2020-12-04 | MTBLS1983 | MetaboLights
UnknownProgressive multifocal leukoencephalopathy secondary to rituximab-induced immunosuppression and the presence of John Cunningham virus: a case report and literature review.
Not available
S-EPMC4996919 | biostudies-literature
UnknownExamining long-term trends in politics and culture through language of political leaders and cultural institutions.
Not available
S-EPMC6397582 | biostudies-literature
UnknownBlood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium.
Not available
S-EPMC6687740 | biostudies-literature
MetabolomicsEnterococcus faecalis readily adapts membrane phospholipid composition to environmental and genetic perturbation

The bacterial lipid membrane, consisting both of fatty acid (acyl) tails and polar head groups, responds to changing conditions through alteration of either the acyl tails and/or head groups. This plasticity is critical for cell survival as it allows maintenance of both the protective nature of t...

2021-05-17 | MTBLS2080 | MetaboLights
UnknownJust the Facts: Airway management during the coronavirus disease 2019 (COVID-19) pandemic.
Not available
S-EPMC7203167 | biostudies-literature
TranscriptomicsImmune cells direct epithelial maturation during early human lung development
The adult human lung harbours a significant proportion of immune cells, which are known to play a crucial role in both normal lung homeostasis and pathogenesis. In this work, we collected CD45-enriched human lung cells from 6 to 22 week post conception (pcw) and built a single-cell transcriptome and...
ORGANISM(S): Homo sapiens 
2022-12-09 | E-MTAB-11528 | biostudies-arrayexpress
ProteomicsUnbiased proteomic profiling uncovers a targetable GNAS/PKA/PP2A axis in SCLC
Using unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, inhibits SCLC expansion in culture and in vivo. Conversely, GNAS (G-protein ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-06-17 | PXD018209 | Pride
Inhibitor beads Analog specific Kinase proteomics Small cell lung cancer 
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