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TranscriptomicsEffects of Integrating and Non-integrating Reprogramming Methods on Copy Number Variation and Genomic Stability of Human Induced Pluripotent Stem Cells
Human-induced pluripotent stem cells (iPSCs) are derived from differentiated somatic cells using defined factors and provide a renewable source of autologous cells for cell therapy. Many reprogramming methods have been employed to generate human iPSCs, including the use of integrating vectors and no...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-69632 | biostudies-arrayexpress
TranscriptomicsDefining Differentiated Methylation Regions Especial for Pluripotency Acquisition and Maintenance in Human Stem Cell
Here, we determined the DNA methylation profiles of 12 human cell lines, including 2 ESC lines, 2 pESC lines,4 virally-delivered iPSC lines, 2 episomal-delivered iPSC lines, and 2 parent cell lines that iPSCs derived from using Illumina’s Infinium HumanMethylation450. The iPSCs exhibited a hypermeth...
ORGANISM(S): Homo sapiens 
2014-05-29 | E-GEOD-57992 | biostudies-arrayexpress
TranscriptomicsFY-hESC Micro-array raw data
Human embryonic stem cells (hESCs) exhibit a skewed X chromosome inactivation (XCI) have recently been reported. Whether there is any copy number variation (CNV), loss of heterozygousity (LOH) and single nucleotide variant (SNV) in those epigenetically distinct cells and whether these abnormalities ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-MTAB-1992 | biostudies-arrayexpress
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