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ProteomicsPHACTR1, a coronary artery disease risk gene, drives endothelial dysfunction
Recent genome-wide association studies have identified PHACTR1 as a critical risk gene associated with polyvascular diseases. However, it remains elusive how PHACTR1 is involved in endothelial dysfunction. Here, we show that PHACTR1 triggers endothelial inflammation by activating NF-κB and disrupts ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-16 | PXD034213 | Pride
Endothelial dysfunction  inflammation  phactr1  nitric oxide  innate immunity  coronary artery disease 
TranscriptomicsNon-invasive Analysis of the Airway Transcriptome Discriminates Clinical Phenotypes of Asthma
BACKGROUND: Evaluation of the airway transcriptome may reveal patterns of gene expression that are associated with clinical phenotypes of asthma. To define transcriptomic endotypes of asthma (TEA) we analyzed gene expression in induced sputum that correlate with phenotypes of disease. METHODS: Ge...
ORGANISM(S): Homo sapiens 
2014-04-07 | E-GEOD-56396 | biostudies-arrayexpress
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