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ProteomicsSDH deficiency-driven succinate accumulation dictates the drug resistance of AML through regulating p-UBC12/cullin activity
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct microenvironment-associated metabolic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD047175 | Pride
Sdh deficiency  succinate  drug resistance  ubc12 phosphorylation  acute myeloid leukemia. 
MetabolomicsTranscriptomic and metabolomic analyses reveal the differential accumulation of phenylpropanoids and terpenoids in hemp autotetraploid and its diploid progenitor

Background

Cannabis sativa, a dioecious plant that has been cultivated worldwide for thousands of years, is known for its secondary metabolites, especially cannabinoids, which possess several medicinal effects. In this study, we investigated the autopolyploidization effects on the biosynthes...
2023-09-21 | MTBLS6032 | MetaboLights
UnknownSmilosicyopus leprurus (Teleostei: Gobiidae) is a Fin-eater.
Not available
S-EPMC6511814 | biostudies-literature
MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
TranscriptomicsBeauveria bassiana SNF 1 (BbSNF1) regulating genes involved in conidiation
Gene BbSNF1 playes an essential role in mediating metabolism and cell development during conidation, a determinant to the biocontrol potential of entomopathogenic fungi. The genome-wide exprssion analysis involved in fungal conidiation was analyzed by using high throughput sequencing (RNA-Seq). Ou...
ORGANISM(S): Beauveria bassiana ARSEF 2860 
2016-07-24 | E-GEOD-60002 | biostudies-arrayexpress
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
UnknownPhytochemical Profile and Antioxidant Activity of the Tuber and Peel of <i>Pachyrhizus erosus</i>.
Not available
S-EPMC12023986 | biostudies-literature
UnknownDietary Polyphenol Intake and Risk of Hypertension: An 18-y Nationwide Cohort Study in China.
Not available
S-EPMC10447504 | biostudies-literature
UnknownPosttranslational Modification Defects in Fibroblast Growth Factor Receptor 1 as a Reason for Normosmic Isolated Hypogonadotropic Hypogonadism.
Not available
S-EPMC7704206 | biostudies-literature
UnknownSinoseneciotongziensis (Asteraceae), a new species from north Guizhou, China.
Not available
S-EPMC11868800 | biostudies-literature
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