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TranscriptomicsEffect of HE4 overexpression or treatment with recombinant HE4 protein on OVCAR8 ovarian cancer cells
The ovarian cancer biomarker HE4 has been shown to have multiple effects on ovarian cancer pathogenesis. In order to reveal gene regulation upstream of HE4 biological effects in ovarian cancer, HE4 was overexpressed in OVCAR8 wild type ovarian cancer cells and compared to null vector transfected cel...
ORGANISM(S): Homo sapiens 
2018-01-15 | E-MTAB-6366 | biostudies-arrayexpress
ProteomicsHuman Epididymis Protein 4 Promotes Aberrant Epithelial-Fibroblast Crosstalk in Pulmonary Fibrosis
Invasive lung myofibroblasts are the main cause of tissue remodeling in idiopathic pulmonary fibrosis (IPF). A key mechanism contributing to this important feature is aberrant crosstalk between the abnormal/injured lung epithelium and pulmonary fibroblasts. Here, we demonstrated that lungs from pati...
ORGANISM(S): Homo Sapiens 
2024-12-17 | PXD058959 |
UnknownThe NF-κB-HE4 axis: A novel regulator of HE4 secretion in ovarian cancer.
Not available
S-EPMC11611113 | biostudies-literature
UnknownHE4 (WFDC2) gene overexpression promotes ovarian tumor growth.
Not available
S-EPMC3880958 | biostudies-literature
GenomicsHE4 regulates anticancer immune evasion by upregulating PD-L1 expression on macrophages through the IFN-γR-STAT3 axis [L1MKK]
HE4 regulates anticancer immune evasion by upregulating PD-L1 expression on macrophages through the IFN-γR-STAT3 axis [L1MKK]
PRJNA1378694 | ENA
GenomicsHE4 regulates anticancer immune evasion by upregulating PD-L1 expression on macrophages through the IFN-γR-STAT3 axis
HE4 regulates anticancer immune evasion by upregulating PD-L1 expression on macrophages through the IFN-γR-STAT3 axis
PRJNA1268911 | ENA
TranscriptomicsHE4 regulates anticancer immune evasion by upregulating PD-L1 expression on macrophages through the IFN-γR-STAT3 axis
Current immune checkpoint inhibitors (ICIs) targeting PD-L1/PD-1 have achieved great success in clinical cancer treatment. However, it still faces great challenges, such as a low overall response rate and immune-related adverse events (irAEs). PD-L1 is transcriptionally induced by immune cell-secret...
ORGANISM(S): Homo sapiens 
2026-02-13 | GSE298300 | GEO
TranscriptomicsHE4 regulates anticancer immune evasion by upregulating PD-L1 expression on macrophages through the IFN-γR-STAT3 axis [L1MKK]
Current immune checkpoint inhibitors (ICIs) targeting PD-L1/PD-1 have achieved great success in clinical cancer treatment. However, it still faces great challenges, such as a low overall response rate and immune-related adverse events (irAEs). PD-L1 is transcriptionally induced by immune cell-secret...
ORGANISM(S): Mus musculus 
2026-02-13 | GSE313133 | GEO
GenomicsHE4 regulates anticancer immune evasion by upregulating PD-L1 expression on macrophages through the IFN-γR-STAT3 axis [RNA-Seq - cell line]
HE4 regulates anticancer immune evasion by upregulating PD-L1 expression on macrophages through the IFN-γR-STAT3 axis [RNA-Seq - cell line]
PRJNA1269982 | ENA
UnknownHE4 Predicts Progressive Fibrosis and Cardiovascular Events in Patients With Dilated Cardiomyopathy.
Not available
S-EPMC8475713 | biostudies-literature
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