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MetabolomicsVolatilomic insight of head and neck cancer via the effects observed on saliva metabolites
Head and neck cancer (HNC) is a heterogeneous malignant disease with distinct global distribution. Metabolic adaptations of HNC are significantly gaining clinical interests nowadays. Here, we investigated effects of HNC on differential expression of volatile metabolites in human saliva. We applied h...
2019-06-03 | MTBLS760 | MetaboLights
MetabolomicsGlobal analysis of plasma lipidomics reveals altered lipid signatures in patients with osteonecrosis of the femoral head

AIMS: Although studies have made the connection between lipid metabolism disorder and osteonecrosis of the femoral head (ONFH), the characteristics of the circulating lipidome signature of ONFH have not yet been investigated yet and need to be explored.

METHODS:

2021-07-06 | MTBLS2262 | MetaboLights
MetabolomicsPhosphatidylcholine in wheat anthers is a susceptibility factor for Fusarium head blight

Non-targeted metabolomics was performed to investigate the metabolic differences between fertile and sterile wheat anthers, and to identify anther-derived metabolites that promote Fusarium head blight infection. Wheat anthers (fertile, sterile, and fertile anthers co-cultured with Fusarium gramin...

2026-06-23 | MTBLS14831 | MetaboLights
TranscriptomicsAntitumor Activity of (R,R’)-4-methoxy-1-naphthylfenoterol in a rat C6 glioma xenograft model in the mouse
(R,R’)-4-methoxy-1-naphthylfenoterol (MNF) inhibits in vitro proliferation of several types of cancer cell lines. In this study, the in vivo antitumor effects of MNF were evaluated using rat C6 glioma cells implanted subcutaneously into the lower flank of 5 week-old NMRI/Nude female Swiss mice. Thre...
ORGANISM(S): Rattus norvegicus 
2015-08-06 | E-GEOD-45307 | biostudies-arrayexpress
GenomicsR-loop landscapes in yeast meiosis
R-loop landscapes in yeast meiosis
PRJNA705491 | ENA
TranscriptomicsA 3'-UTR KRAS-variant is associated with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.
To determine the differential expression of KRAS-variant HNSCC (head and neck squamous cell carcinoma) cell lines. Total RNA collected from a panel of HNSCC cell lines.
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-36110 | biostudies-arrayexpress
TranscriptomicsHNSCC Cells: ctrl vs six tumour lethal miRNAs transfected
Some microRNAs have antiproliferative effects in cells and are believed to act as tumour suppressors. We used a retroviral human microRNA expression library to identify six microRNAs, miR-181a, miR-323, miR-326, miR-342, miR345 and miR-371, that induce antiproliferative effects in head and neck squa...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-34881 | biostudies-arrayexpress
GenomicsSenataxin regulates cisplatin resistance through an R-loop mediated mechanism in HPV-associated Head and Neck Cancer
Senataxin regulates cisplatin resistance through an R-loop mediated mechanism in HPV-associated Head and Neck Cancer
PRJNA1170248 | ENA
TranscriptomicsSmall-RNA high-throughput sequencing of head-and-neck cancer with or without human papilloma virus etiology
HPV positive head and neck cancer (HNC) are thought to have different etiology from HPV-unrelated HNC. There are indications that HPV positive HNC have better survival and that treatment options could be optimized in this set of tumours. In this study, we sought to evaluate miRNA profiles in the dif...
ORGANISM(S): Homo sapiens 
2019-02-20 | E-MTAB-7030 | biostudies-arrayexpress
TranscriptomicsRNA-Seq count data from fresh oral an oropharyngeal tissue samples from head and neck squamous cell carcinoma patients and fresh tonsil tissue samples from control patients
Integration of transcriptome with miRNome and methylome data aiming to elucidate role of epigenetics on gene expression in head and neck squamous cell carcinoma.
ORGANISM(S): Homo sapiens 
2024-04-22 | E-MTAB-13725 | biostudies-arrayexpress
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