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Unknown (28129)
Genomics (1717)
Transcriptomics (1185)
Clinical (291)
Proteomics (189)
Other (54)
Methylation profiling (42)
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Organisms

Homo sapiens (1420)
Mus musculus (214)
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synthetic construct (10)
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Mytilus galloprovincialis (3)
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Paralichthys olivaceus (1)
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Phaeodactylum tricornutum (1)
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human gammaherpesvirus 4 (1)
Betapolyomavirus hominis (1)

Organisms

Homo sapiens (889)
Mus musculus (145)
Rattus norvegicus (8)
Gallus gallus (4)
Canis lupus familiaris (4)
Oryctolagus cuniculus (3)
Streptococcus pneumoniae D39 (2)
Mus (2)
human metagenome (2)
Homo (2)
metagenome (2)
Streptococcus pneumoniae R6 (1)
Myxococcus phage Mx4 (1)
Melopsittacus undulatus (1)
Fusobacterium nucleatum (1)
Human immunodeficiency virus (1)
Aquarana catesbeiana (1)
Caudoviricetes (1)
unidentified (1)
Bacteria (1)
human oral metagenome (1)
human saliva metagenome (1)
Felis catus (1)
Bacillus subtilis (1)
mixed sample (1)
Danio rerio (1)

Repository

ENA (1349)
geo (821)
biostudies-arrayexpress (638)
EGA (181)
pride (123)
MassIVE (32)
iProX (20)
dbGaP (16)
MetaboLights (14)
ExpressionAtlas (7)
PanoramaPublic (6)
GNPS (5)
jPOST (5)
BioModels (2)
EVA (2)
GPMDB (2)
MetabolomicsWorkbench (1)
PeptideAtlas (1)

Tissue

Lung (11)
Skin (7)
Brain (6)
Blood (6)
Breast (5)
Liver (5)
Kidney (5)
Uterine cervix (3)
Esophagus (3)
Large intestine (3)
Stomach (3)
Pancreas (3)
Ovary (3)
Uterus (3)
Urinary bladder (3)
Prostate gland (3)
Thyroid gland (3)
Mouth mucosa (2)
Skeletal muscle tissue (2)
Musculature (1)
Hematopoietic system (1)
Peripheral nervous system (1)
Vulva (1)
Mucosa (1)
Connective tissue (1)
Bile duct (1)
Bone (1)
Placenta (1)
Gall bladder (1)
Adrenal gland (1)

Disease

Head and neck squamous cell carcinoma (36)
Melanoma (7)
Cholangiocarcinoma (6)
Follicular thyroid carcinoma (5)
Renal cell carcinoma (4)
Pancreatic adenocarcinoma (4)
Gastric adenocarcinoma (4)
Hepatocellular carcinoma (4)
Bladder transitional cell carcinoma (4)
Invasive lobular carcinoma (4)
Squamous cell lung carcinoma (4)
Cervical squamous cell carcinoma (4)
Ovarian adenocarcinoma (4)
Esophageal adenocarcinoma (4)
Lung adenocarcinoma (4)
Breast adenocarcinoma (4)
Sarcoma (4)
Cervical adenocarcinoma (3)
Lymphoma (3)
Glioblastoma multiforme (3)
Colorectal adenocarcinoma (3)
Prostate adenocarcinoma (3)
Chronic lymphocytic leukemia (3)
Endometrial adenocarcinoma (3)
Glioma (3)
Bladder carcinoma (3)
Anaplastic astrocytoma (2)
Chondrosarcoma (2)
Hodgkins lymphoma (2)
Mesothelioma (2)

Technology Type

Mass Spectrometry (124)
Shotgun proteomics (66)
Bottom-up proteomics (22)
Data-dependent acquisition (15)
Mass spectrometry (11)
Data-independent acquisition (11)
Affinity purification coupled with mass spectrometry proteomics (10)
Illumina HiSeq 2000 (8)
Gel-based experiment (8)
MSE (4)
Top-down proteomics (4)
SWATH MS (3)
ILLUMINA, Illumina HiSeq 2000 (2)
Mass spectrometry assay (2)
DiaPASEF (2)
SRM/MRM (2)
Illumina MiSeq, Illumina HiSeq 2000, ILLUMINA (1)
Illumina HumanExome Array (1)
NextSeq 500, Illumina HiSeq 2500, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2500, HiSeq X Ten (1)
Illumina HiSeq 2500, ILLUMINA (1)
Illumina HiSeq 2000, Infinium HumanMethylation450 BeadChip (1)
Illumina HiSeq 2500, Illumina MiSeq (1)
454 GS FLX Titanium, Illumina HiSeq 2000 (1)
Illumina HiSeq 2500 (1)
Illumina HiSeq 2000, ILLUMINA (1)
NMR spectroscopy (1)
ESI (1)
HDMSE (1)
Mass spectrometry imaging (1)

Instrument Platform

Illumina NovaSeq 6000 (19)
NextSeq 500 (14)
Illumina HiSeq 2500 (11)
Illumina HiSeq 2000 (7)
Illumina HiSeq 4000 (5)
Linux server, HPC cluster (2)
Thermal cycler (Bio-Rad C1000), Agilent 2100 Bioanalyzer, Qubit 4 Fluorometer (2)
Benchtop centrifuge, vortex, NanoDrop or plate reader (for RiboGreen assay), TapeStation (Agilent) (2)
Liquid nitrogen freezer, surgical instruments (2)
Ion Chef (2)
Illumina MiSeq (2)
Ion Torrent S5 XL (2)
Illumina HiSeq 1500 (2)
NextSeq 550 (2)
Genechip Scanner 3000 7G (1)
Thermal cycler, Magnetic stand / beads, Pipettes and tips, Microcentrifuge tubes, Plate shaker (1)
Centrifuge, Pipettes and tips, Agilent 2100 Bioanalyzer, NanoDrop spectrophotometer, Vortex mixer (1)
Liquid nitrogen, -80°C freezer, Surgical tools (scalpels, forceps), Sample tubes / cryovials (1)
Single nuclei were captured using the 10x Genomics Chromium Controller. (1)
Thermo Fisher (1)
Not applicable in this study (1)
Qubit instrument, DNA HS kit (1)
High Sensitivity DNA kit (1)
BioRad SureCell (1)
DNA microarray scanner (Agilent #G2565CA) (1)
Illumina BeadArray Reader (part of Illumina BeadStation 500 (1)
ISCAN (1)
None (1)
Unspecified (1)
The TLDA cards were analyzed on the Applied Biosystems 7900HT Real-Time PCR System. (1)

Publication Date

2025 (150)
2024 (130)
2023 (119)
2013 (117)
2026 (113)
2022 (108)
2014 (99)
2021 (97)
2012 (92)
2016 (90)
2015 (79)
2011 (78)
2010 (68)
2020 (62)
2018 (54)
2019 (49)
2017 (42)
2008 (41)
2009 (38)
2007 (14)
2005 (12)
2006 (9)
2004 (2)

UNIPROT ID/AC

A0A024R563 (1)
A0A024RAN2 (1)
A0A024RC46 (1)
A5A3E0 (1)
A6NHL2 (1)
A6NNZ2 (1)
B2RPK0 (1)
B2RXF3 (1)
B3KML9 (1)
B3KT93 (1)
B4DHB3 (1)
B4DPR2 (1)
B4DRV9 (1)
B4E3A4 (1)
C9JM50 (1)
C9JZR2 (1)
D3DPU2 (1)
E7EX29 (1)
E9PB61 (1)
E9PC52 (1)
F8VRH0 (1)
G8JLB6 (1)
H0YM50 (1)
H7BY16 (1)
H7BZ94 (1)
H7C144 (1)
I3L3D5 (1)
I3L4N8 (1)
J3KPS3 (1)
J3KRE2 (1)

CHEBI ID

CHEBI:17822 (5)
CHEBI:15428 (5)
CHEBI:15676 (4)
CHEBI:18211 (4)
CHEBI:27226 (4)
CHEBI:17533 (4)
CHEBI:37024 (4)
CHEBI:17509 (4)
CHEBI:7916 (4)
CHEBI:16027 (4)
CHEBI:16335 (4)
CHEBI:16737 (4)
CHEBI:16199 (4)
CHEBI:17191 (4)
CHEBI:30769 (4)
CHEBI:17057 (3)
CHEBI:32797 (3)
CHEBI:29042 (3)
CHEBI:17768 (3)
CHEBI:5417 (3)
CHEBI:18283 (3)
CHEBI:26271 (3)
CHEBI:17202 (3)
CHEBI:22660 (3)
CHEBI:18186 (3)
CHEBI:16811 (3)
CHEBI:28300 (3)
CHEBI:25017 (3)
CHEBI:16610 (3)
CHEBI:144829 (1)

Metabolite Name

Leucine (6)
Creatinine (6)
Creatine (5)
Phenol (4)
Histidine (4)
Valine (4)
Tyrosine (4)
Adenosine (4)
Phenylalanine (4)
Ethanol (3)
Phenylacetaldehyde (3)
Glycine (3)
Betaine (3)
Cellobiose (3)
Phytosphingosine (3)
Choline (3)
Cholic acid (3)
Lysine (3)
Serine (3)
Spermidine (3)
Guanine (3)
Alanine (3)
Proline (3)
Isoleucine (3)
Adenine (3)
Urea (3)
Glycerophosphocholine (3)
Inosine (3)
Hypoxanthine (3)
4,7,10,13-docosatetraenoic acid (2)

First Public Date

2025 (184)
2014 (164)
2026 (162)
2024 (161)
2023 (133)
2021 (109)
2022 (108)
2020 (81)
2018 (71)
2019 (50)
2017 (47)
2016 (33)
2015 (25)
2013 (21)

Modelling Approach

Finite element spatial model (1)
Ordinary differential equation model (1)

Study status

Completed (103)
Recruiting (98)
Active, not recruiting (31)
Terminated (29)
Not provided (14)
Not yet recruiting (7)
Withdrawn (4)
Ongoing (2)
Available (2)
Enrolling by invitation (1)

Lab affiliation

Department of Molecular Cell Biology, Weizmann institute of Science, Israel (5)
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205 USA (4)
Department of Physiology and Biophysics, University of Illinois at Chicago (3)
Washington University in St. Louis (3)
1 Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, P.O.Box 263, FI-00029 HUS, Helsinki, Finland 2 Department of Biosciences and Nutrition, Karolinska Institutet, SE-171 76, Stockholm, Sweden. 3 Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. (2)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (2)
Institute of Bioinformatics , International Technology Park, Bangalore, India (2)
Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch (2)
1. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. 2. Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan. 3. Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou 33305, Taiwan. 4. Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33302, Taiwan. (1)
1.Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2.Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China 3.Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China (1)
1State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China.2 Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China. (1)
9McKusick-Nathans Institute of Genetic Medicine, 10Departments of Biological Chemistry, and 11Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. (1)
Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), TUM School of Life Sciences, Technical University of Munich, Freising, Germany (1)
Bavarian Center for Biomolecular Mass Spectrometry at Klinikum rechts der Isar (BayBioMS@MRI), TUM School of Medicine and Health, Technical University of Munich (TUM), 81675 München, Germany (1)
Beijing Key Laboratory of DNA Damage Response and College of Life Science, Capital Normal University, Beijing 100048, China (1)
Biomedical Research in Cancer Stem Cells Group,Pathology Department, Collserola Building, Lab 205,Vall d'Hebron Research Institute (VHIR, Passeig Vall d'Hebron 119-129,Barcelona 08035, Spain. Tel: +34-93-489-4169 FAX: +34-93-274-6708 (1)
Biomedical Research in Cancer Stem Cells, Vall d’Hebron Research Institute (VHIR), Autonomous University of Barcelona, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain; (1)
Biotechnology Research and Innovation Council, National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, 741251, India. (1)
CNRS-IPHC-LSMBO (1)
CRCM (Marseille Protéomique), Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université, UM105, CNRS UMR7258, Marseille (1)
CSSB Centre for Structural Systems Biology c/o Deutsches Elektronen-Synchrotron DESY Notkestraße 85, Building 15 D-22607 Hamburg (1)
Cancer Research Institute, School of Basic Medical Science, Central South University (1)
Center Leader Proteomics Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS) Technical University Munich (TUM) Gregor-Mendel-Straße 4 85354 Freising GERMANY (1)
Center for Biomedical Mass Spectrometry Boston University School of Medicine 670 Albany St, Rm 511 Boston, MA 02118-2646 USA (1)
Center for Systems Biology and Molecular Medicine Yenepoya Research Centre Yenepoya (Deemed to be University) University Road, Deralakatte Mangalore 575018, India (1)
Centre for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia. (1)
Department Cellular and Molecular Medicine KU Leuven Belgium (1)
Department for Proteomics, Center for Translational and Clinical Research, School of Medicine, University of Zagreb Department of Anatomy “Drago Perović”, School of Medicine, University of Zagreb (1)
Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India (1)
Department of Biochemistry, Western University, Canada (1)

Keyword

Pembrolizumab (39)
Cetuximab (23)
Immunotherapy (21)
Nivolumab (21)
Recurrent colon cancer (14)
EGFR (13)
CRC (13)
HNSCC (12)
Stage IV colon cancer (12)
Stage IV breast cancer (10)
Recurrent breast cancer (10)
Recurrent non-small cell lung cancer (10)
Stage IV salivary gland cancer (9)
Recurrent salivary gland cancer (9)
Stage IV squamous cell carcinoma of the hypopharynx (9)
Recurrent squamous cell carcinoma of the hypopharynx (9)
Stage IV squamous cell carcinoma of the larynx (9)
Recurrent squamous cell carcinoma of the larynx (9)
Stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity (9)
Recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity (9)
Recurrent metastatic squamous neck cancer with occult primary (9)
Stage IV squamous cell carcinoma of the lip and oral cavity (9)
Recurrent squamous cell carcinoma of the lip and oral cavity (9)
Stage IV squamous cell carcinoma of the oropharynx (9)
Recurrent squamous cell carcinoma of the oropharynx (9)
Stage IV squamous cell carcinoma of the nasopharynx (9)
Recurrent squamous cell carcinoma of the nasopharynx (9)
Stage IIIB breast cancer (9)
Stage IIIA breast cancer (9)
SCCHN (9)

IsPrivate

False (2)

Submitter Keywords

Immuno-oncology (1)

Classification

bacteria (4)
viruses (3)

Modification

N6 (2)

Study type

Transcription profiling by array (375)
RNA-seq of coding RNA (63)
ChIP-seq (46)
Comparative genomic hybridization by array (37)
Methylation profiling by array (33)
MicroRNA profiling by array (9)
RNA-seq of non coding RNA (8)
Genotyping by array (7)
Unknown experiment type (6)
Other (6)
RNA-seq of coding RNA from single cells (6)
DNA-seq (5)
RNA-seq of total RNA (5)
ATAC-seq (4)
Transcription profiling by SAGE (3)
Human - Methylation microarray (3)
Cell line - High-throughput sequencing (3)
ChIP-chip by tiling array (2)
MicroRNA profiling by high throughput sequencing (2)
Spatial transcriptomics by high-throughput sequencing (2)
Methylation profiling by high throughput sequencing (2)
Animal - Methylation microarray (1)
Cell line - Single-cell sequencing (1)
Human - Two-color microarray (1)
Whole chromosome random sequencing (1)
Human - One-color microarray (1)
RNAi profiling by array (1)
Transcription profiling by RT-PCR (1)
Exome sequencing (1)
Single nucleus RNA sequencing (1)

Release Date

2022 (3745)
2025 (3667)
2023 (3436)
2021 (3289)
2024 (2990)
2020 (2363)
2019 (1654)
2018 (1425)
2017 (1192)
2016 (1091)
2015 (848)
2014 (714)
2026 (520)
2013 (440)
2012 (356)
2011 (326)
2010 (240)
2009 (175)
2008 (110)
2007 (44)
2006 (43)
2005 (35)
2004 (19)
2003 (15)
2002 (9)
2001 (7)
2000 (7)
1997 (3)
1999 (2)

Location

United States (197)
Australia (35)
United Kingdom (31)
Spain (31)
France (29)
Canada (28)
Germany (23)
Belgium (22)
Italy (20)
China (20)
Netherlands (20)
South Korea (19)
Japan (13)
Taiwan (11)
Denmark (11)
Switzerland (9)
Poland (7)
Austria (7)
Hong Kong (6)
Singapore (6)
Israel (6)
Brazil (6)
Czechia (4)
India (3)
Argentina (3)
Sweden (3)
Oceania (2)
Guam (2)
Georgia (2)
Asia except Japan (2)

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Volatilomic insight of head and neck cancer via the effects observed on saliva metabolites

Head and neck cancer (HNC) is a heterogeneous malignant disease with distinct global distribution. Metabolic adaptations of HNC are significantly gaining clinical interests nowadays. Here, we investigated effects of HNC on differential expression of volatile metabolites in human saliva. We applied h...

2019-06-03 | MTBLS760 | MetaboLights

Gene expression profiles of head and neck squamous cell carcinoma

Sage performed on microdissection of Head and Neck tumor, and Head and Neck normal tissue comparative analysis of gene expression profiles of head and neck squamous cell carcinoma and Head and Neck normal tissue

ORGANISM(S): Homo sapiens

2008-09-30 | E-GEOD-11986 | biostudies-arrayexpress

Transcription profiling of human head and neck paired diseased squamous cell carcinoma samples vs normal

Forty-four paired (from the same patient) samples of head and neck squamous cell carcinoma (HNSCC) and normal tissue were studied with Affymetrix U95A chips. A stringent multi-test approach, combining 7 traditional and microarray-specific statistical tests, was used to analyze the resultant data. Ca...

ORGANISM(S): Homo sapiens

2009-02-06 | E-GEOD-6631 | biostudies-arrayexpress

MethylationEPIC array from fresh oral and oropharyngeal tissue samples from head and neck squamous cell carcinoma patients, tissue samples from potentially premalignant oral lesions and fresh tonsil tissue samples from control patients

This data was used to detect good biomarkers for head and neck squamous cell carcinoma and was integrated with transcriptome and miRNome data aiming to elucidate role of epigenetics on gene expression in head and neck squamous cell carcinoma.

ORGANISM(S): Homo sapiens

2024-04-22 | E-MTAB-13954 | biostudies-arrayexpress

HNSCC Cells: ctrl vs six tumour lethal miRNAs transfected

Some microRNAs have antiproliferative effects in cells and are believed to act as tumour suppressors. We used a retroviral human microRNA expression library to identify six microRNAs, miR-181a, miR-323, miR-326, miR-342, miR345 and miR-371, that induce antiproliferative effects in head and neck squa...

ORGANISM(S): Homo sapiens

2013-11-06 | E-GEOD-34881 | biostudies-arrayexpress

RNA-Seq count data from fresh oral an oropharyngeal tissue samples from head and neck squamous cell carcinoma patients and fresh tonsil tissue samples from control patients

Integration of transcriptome with miRNome and methylome data aiming to elucidate role of epigenetics on gene expression in head and neck squamous cell carcinoma.

ORGANISM(S): Homo sapiens

2024-04-22 | E-MTAB-13725 | biostudies-arrayexpress

Global hypomethylation identifies loci targeted for hypermethylation in head and neck cancer

This SuperSeries is composed of the following subset Series: GSE25083: Global hypomethylation identifies loci targeted for hypermethylation in head and neck cancer: normal head and neck tissue GSE25089: Global hypomethylation identifies loci targeted for hypermethylation in head and neck cancer: HNS...

ORGANISM(S): Homo sapiens

2011-10-27 | E-GEOD-25093 | biostudies-arrayexpress

Quantitative multi-Omics analysis of paclitaxel-loaded Poly(lactide-co-glycolide) nanoparticles for identification of potential biomarkers for head and neck cancer

Not available

ORGANISM(S): Homo sapiens

ST002248 | MetabolomicsWorkbench

miRNA expression in head and neck squamous cell carcinoma (HNSCC)

The involvement of microRNAs (miRNAs) in cancer and their potential as biomarkers of diagnosis, prognosis and response to therapy is becoming increasingly appreciated. The etiology of head and neck squamous cell carcinoma (HNSCC) is predominantly associated with the synergistic effects of tobacco an...

ORGANISM(S): Homo sapiens

2010-05-19 | E-GEOD-11163 | biostudies-arrayexpress

Global hypomethylation identifies loci targeted for hypermethylation in head and neck cancer: HNSCC

Genome-wide DNA methylation profiling of head and neck squamous cell carcinomas (HNSCCs). The Illumina Infinium 27k Human DNA methylation BeadChip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in fresh-frozen tumor tissues. Samples included 91 tumors from the oral...

ORGANISM(S): Homo sapiens

2011-10-27 | E-GEOD-25089 | biostudies-arrayexpress