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Proteomic analyses found enrichment of ciliary-related factors in male pedicels compared to females, potentially underlying sexual dimorphisms in hearing systems.
ORGANISM(S): Cellular Organisms 
Age-related hearing loss (AHL) is the progressive loss of auditory function with aging. The DBA/2J (DBA) mice have been used as a model of AHL and undergoes progressive, age-related hearing loss by 12 weeks of age. Here we analyzed cochlear gene expression of 7-week-old and 36-week-old DBA mice usin...
ORGANISM(S): Mus musculus 
Mitochondrial DNA (mtDNA) mutations may contribute to aging and age-related disorders. Previously, we created mice expressing a proofreading-deficient version of the mtDNA polymerase gamma (Polg) which accumulate age-related mtDNA mutations and display premature aging. Here we performed microarray g...
ORGANISM(S): Mus musculus 
Exome resequencing of progressive hearing loss.
Treatment of DBA/2J mice with a combination of L-methionine and valproic acid significantly attenuated progressive hearing loss. We examined gene expression in the whole cochlea of the mice. This study was aimed to detect genes of which change in expression levels were associated with attenuation of...
ORGANISM(S): Mus musculus 
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